CD81 通过阻断 CD274/PD-L1 的选择性自噬降解驱动放射抵抗性胶质母细胞瘤的免疫逃逸
CD81 drives immune evasion in radioresistant glioblastoma by blocking selective autophagic degradation of CD274/PD-L1.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
肿瘤微环境中巨噬细胞网络调控的纳米治疗：靶点与工具
英文原题：Nanotherapeutics for Macrophage Network Modulation in Tumor Microenvironments: Targets and Tools.
查看英文原题
Nanotherapeutics for Macrophage Network Modulation in Tumor Microenvironments: Targets and Tools.
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中文摘要
巨噬细胞是肿瘤免疫微环境中的重要组成部分，对肿瘤的发展和转移具有显著影响。由于巨噬细胞具有促炎和抑炎的双重特性，它们既可以作为肿瘤免疫治疗的靶点，也可以作为治疗恶性肿瘤的工具。然而，以免疫抑制表型为主的肿瘤相关巨噬细胞大量浸润，维持了促肿瘤微环境，而利用纳米技术工程化巨噬细胞来调控肿瘤免疫微环境，是一种可行的肿瘤免疫治疗策略。此外，考虑到M1型巨噬细胞的吞噬能力和特异性肿瘤靶向能力，通过细胞工程和纳米技术操控的巨噬细胞，以及巨噬细胞来源的外泌体和巨噬细胞膜，也可以成为有效的肿瘤治疗工具。总之，靶向巨噬细胞的纳米治疗在开发巨噬细胞介导的肿瘤治疗方法方面仍具有巨大潜力，并将进一步增进我们对各种恶性肿瘤的认识、诊断和治疗。
展开英文摘要原文
Macrophage is an important component in the tumor immune microenvironment, which exerts significant influence on tumor development and metastasis. Due to their dual nature of promoting and suppressing inflammation, macrophages can serve as both targets for tumor immunotherapy and tools for treating malignancies.
However, the abundant infiltration of tumor-associated macrophages dominated by an immunosuppressive phenotype maintains a pro-tumor microenvironment, and engineering macrophages using nanotechnology to manipulate the tumor immune microenvironment represent a feasible approach for cancer immunotherapy.
Additionally, considering the phagocytic and specifically tumor-targeting capabilities of M1 macrophages, macrophages manipulated through cellular engineering and nanotechnology, as well as macrophage-derived exosomes and macrophage membranes, can also become effective tools for cancer treatment.
In conclusion, nanotherapeutics targeting macrophages remains immense potential for the development of macrophage-mediated tumor treatment methods and will further enhance our understanding, diagnosis, and treatment of various malignants.
论文信息
- 作者
- Li R、Huang J、Wei Y、Wang Y、Lu C、Liu J、Ma X
- 单位
- Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China.China
- 文献类型
- 综述
- 期刊
- International journal of nanomedicine2024
- 原文标识
- PubMed 39717515 · DOI 10.2147/IJN.S491573
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