CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
嵌合抗原受体修饰 T 细胞治疗后早期与晚期感染并发症
英文原题：Early versus late infectious complications following chimeric antigen receptor-modified T-cell therapy.
查看英文原题
Early versus late infectious complications following chimeric antigen receptor-modified T-cell therapy.
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中文摘要
尽管CAR-T 细胞疗法的应用日益增多，但有关输注后早期阶段之后的长期随访及感染并发症风险的数据仍不足。本研究旨在比较早期感染（3个月内）和晚期感染（3个月至1年）的流行病学特征及危险因素。研究回顾性收集本机构所有连续接受治疗的成年患者在6个时间点的数据：CAR-T 治疗前、输注当日，以及CAR-T 输注后3、6、9和12个月。本队列首年任何感染的累积发生率为73.2%。桥接治疗、细胞因子释放综合征（CRS）、神经毒性和类固醇使用被确定为早期细菌感染的相关危险因素。3个月后，社区获得性呼吸道感染较为常见。研究根据CAR-T 细胞输注后的时间，描述了细菌、病毒和真菌病原体。
展开英文摘要原文
Despite increasing utilization of CAR T-cell therapy, data are lacking regarding long term follow up and risk of infectious complications after the early period following CAR T-cell infusion. In this study, we sought to compare epidemiology and risk factors for early ( 3 months) and late (3 months to 1 year) infections.
Data were retrospectively collected at six time points: pre-CAR T, day of infusion, and at 3, 6, 9, and 12 months post CAR-T infusion for all consecutive adult patients treated at our institution. In this cohort, the cumulative incidence of any infection was 73. 2% in the first year. Bridging therapy, CRS, neurotoxicity and steroid use were identified as contributing risk factors for early bacterial infections. After 3 months, community acquired respiratory infections were common.
We characterize bacterial, viral and fungal pathogens based on time elapsed after CAR T-cell infusion.
论文信息
- 作者
- Bindal P、Trottier CA、Elavalakanar P、Dodge LE、Kim S、Logan E、Ma S、Liegel J
- 第一作者单位
- Division of Oncology, Department of Medicine, University of Massachusetts, Worcester, Massachusetts, USA.United States
- 通讯作者单位
- Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.Israel
- 期刊
- Leukemia & lymphoma2025 Apr
- 原文标识
- PubMed 39704413 · DOI 10.1080/10428194.2024.2439513