CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞治疗成人高级别胶质瘤
英文原题：CAR-T cell therapy for the treatment of adult high-grade gliomas.
查看英文原题
CAR-T cell therapy for the treatment of adult high-grade gliomas.
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中文摘要
尽管治疗不断进步，胶质母细胞瘤等原发性恶性脑肿瘤的治疗仍面临重大挑战。CAR-T 细胞免疫疗法是一种有前景的传统疗法替代方案。本文回顾了靶向脑肿瘤的CAR-T 细胞疗法临床试验概况，重点介绍新靶抗原和联合治疗策略等关键进展；这些策略旨在应对肿瘤异质性和免疫抑制，以改善这类侵袭性癌症患者的结局。
展开英文摘要原文
Treatment for malignant primary brain tumors, including glioblastoma, remains a significant challenge despite advances in therapy. CAR-T cell immunotherapy represents a promising alternative to conventional treatments. This review discusses the landscape of clinical trials for CAR-T cell therapy targeting brain tumors, highlighting key advancements like novel target antigens and combinatorial strategies designed to address tumor heterogeneity and immunosuppression, with the goal of improving outcomes for patients with these aggressive cancers.
论文信息
- 作者
- Park S、Maus MV、Choi BD
- 第一作者单位
- Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.United States
- 通讯作者单位
- Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. bchoi@mgh.harvard.edu.United States
- 文献类型
- 综述
- 期刊
- NPJ precision oncology2024 Dec 19
- 原文标识
- PubMed 39702579 · DOI 10.1038/s41698-024-00753-0
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →