单细胞追踪揭示黑色素瘤 TIL 治疗过程中肿瘤反应性 T 细胞的可塑性
Single-cell tracking reveals tumor-reactive T cell plasticity during melanoma TIL therapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
肿瘤浸润性调节性 T 细胞：肿瘤微环境中一个有前景的治疗靶点
英文原题：Tumor-infiltrating regulatory T cell: A promising therapeutic target in tumor microenvironment.
查看英文原题
Tumor-infiltrating regulatory T cell: A promising therapeutic target in tumor microenvironment.
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中文摘要
调节性T细胞（Tregs）主要通过其免疫抑制功能维持免疫平衡并预防自身免疫。然而，肿瘤浸润性Tregs（TI-Tregs）可能在复杂的肿瘤微环境中介导肿瘤免疫耐受，导致预后不良。近年来，区分特定的TI-Treg亚群与外周Tregs及瘤内常规T细胞（Tconvs）已成为抗肿瘤治疗的重要课题。在本综述中，我们总结了临床前和临床研究中针对TI-Tregs代谢途径和标志性特征的新型治疗策略。尽管TI-Tregs的表型和功能多样性仍不清楚，但本综述为基于TI-Tregs的治疗提供了新见解，并促进了肿瘤治疗的精准医学。
展开英文摘要原文
Regulatory T cell (Tregs) predominantly maintain the immune balance and prevent autoimmunity via their immunosuppressive functions.
However, tumor-infiltrating Tregs (TI-Tregs) may mediate tumor immune tolerance in complex tumor microenvironments, resulting in poor prognosis. Distinguishing specific TI-Treg subpopulations from peripheral Tregs and intratumoral conventional T cells (Tconvs) has recently emerged as an important topic in antitumor therapy.
In this review, we summarize novel therapeutic approaches targeting both the metabolic pathways and hallmarks of TI-Tregs in preclinical and clinical studies. Although the phenotypic and functional diversity of TI-Tregs remains unclear, our review provides new insights into TI-Treg-based therapies and facilitates precision medicine for tumor treatment.
论文信息
- 作者
- Huang T、Li F、Wang Y、Gu J、Lu L
- 单位
- Department of Plastic and Cosmetic Surgery of the Affiliated Friendship Plastic Surgery Hospital & Hepatobiliary Center of the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China.China
- 文献类型
- 综述
- 期刊
- Chinese medical journal2024 Dec 20
- 原文标识
- PubMed 39679474 · DOI 10.1097/CM9.0000000000003450
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