CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞治疗后的戊型肝炎病毒感染：已面临重大健康挑战患者的重要并发症
英文原题：Hepatitis E virus infection after CAR T-cell treatment: An important complication in patients already facing significant health challenges.
查看英文原题
Hepatitis E virus infection after CAR T-cell treatment: An important complication in patients already facing significant health challenges.
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中文摘要
接受嵌合抗原受体（CAR）T 细胞治疗的血液系统恶性肿瘤患者，有发生慢性戊型肝炎病毒感染的风险。临床上保持高度警惕，对于早期诊断并及时治疗这种难治性病毒性肝炎至关重要。本文评述 Schwarz 等人报道的病例：一名弥漫性大 B 细胞淋巴瘤患者 CAR-T 治疗后发生慢性戊型肝炎，并迅速进展为失代偿性肝硬化。《British Journal of Haematology》2025 年；206：977–980。
展开英文摘要原文
Cancer patients with haematological malignancies are at risk for chronic hepatitis E virus infection following chimeric antigen receptor (CAR) T-cell therapy. Strong clinical suspicion is essential for the early diagnosis and prompt treatment of this difficult-to-treat type of viral hepatitis. Commentary on: Schwarz et al. Chronic hepatitis E in a patient after CAR-T cell treatment for diffuse large B-cell lymphoma and rapid progression towards decompensated liver cirrhosis. Br J Haematol 2025; 206:977-980.
论文信息
- 作者
- Mallet V、Torres HA
- 第一作者单位
- Service Hépatologie, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris Université Paris Cité, Paris, France.France
- 通讯作者单位
- Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.United States
- 文献类型
- 社论
- 期刊
- British journal of haematology2025 Mar
- 原文标识
- PubMed 39622628 · DOI 10.1111/bjh.19931