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肿瘤微环境中淋巴细胞浸润作为实体瘤免疫治疗反应预测因素的作用:来自罗马尼亚的单中心经验

英文原题:The Role of Lymphocytic Infiltrates in the Tumor Microenvironment as a Predictive Factor for the Response to Immunotherapy in Solid Tumors: A Single-Center Experience From Romania.

查看英文原题

The Role of Lymphocytic Infiltrates in the Tumor Microenvironment as a Predictive Factor for the Response to Immunotherapy in Solid Tumors: A Single-Center Experience From Romania.

PubMed 2024/11/21(内容时间) Cureus

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中文摘要

TIL(肿瘤浸润淋巴细胞)(TILs)与免疫治疗反应之间的相关性是一个不断发展的领域,具有重要的临床意义。免疫治疗已经彻底改变了抗肿瘤治疗,为诊断为实体瘤的患者提供了有希望的结果。整合生物标志物、改进成像技术以及开发非侵入性方法,可能增强个性化医疗,优化治疗策略,同时尽量减少不良反应。在我们的研究中,我们进行了一项回顾性分析,以评估利用肿瘤微环境(TME)中TIL(肿瘤浸润淋巴细胞)(TILs)的预测价值来关联实体瘤患者免疫治疗反应的实用性,并全面梳理了当前可用的数据。持续的研究努力以及科学家与临床医生之间的合作,对于释放这些生物标志物的全部潜力并推动实体瘤免疫治疗领域的发展至关重要。

展开英文摘要原文

The correlation between tumor-infiltrating lymphocytes (TILs) and immunotherapy responses is an evolving field with significant clinical implications. Immunotherapy has revolutionized antineoplastic therapies, offering promising results for patients diagnosed with solid tumors. Integrating biomarkers, refining imaging techniques, and developing non-invasive methods may enhance personalized medicine, optimizing treatment strategies while minimizing adverse effects.

In our study, we conducted a retrospective analysis to assess the practicality of utilizing the predictive value of tumor-infiltrating lymphocytes (TILs) in the tumor microenvironment (TME) correlating the response to immunotherapy in patients with solid tumors, comprehensively navigating through currently available data. Continued research efforts and collaboration between scientists and clinicians are essential to unlock the full potential of these biomarkers and advance the field of immunotherapy in solid tumors.

论文信息

作者
Mihaila RI、Gheorghe AS、Zob DL、Stanculeanu D
第一作者单位
Oncology Department, University of Medicine and Pharmacy, Bucharest, ROU.Romania
通讯作者单位
Medical Oncology Department, Institute of Oncology "Prof. Dr. Alexandru Trestioreanu", Bucharest, ROU.Romania
期刊
Cureus2024 Nov
原文标识
PubMed 39583615 · DOI 10.7759/cureus.74194