异基因造血细胞移植后抗 CD19 CAR-T 细胞治疗后的移植物抗宿主病：移植并发症与儿科疾病工作组联合 EBMT 研究

In patients diagnosed with B-acute lymphoblastic leukemia (B-ALL) or B-non-Hodgkin's lymphoma (B-NHL) relapsing after allogeneic stem cell transplantation (allo-HCT), it is a standard practice to perform anti-CD19 chimeric antigen receptor (CAR) T-cell therapy. When collected from the patient after allo-HCT, the produced CAR-T cells are likely to be donor T-cell-derived, creating unknown safety risks due to their potential allo-reactivity.

We therefore performed an EBMT registry-based study on the incidence of graft-versus-host disease (GvHD) in this setting.

We included 257 allo-HCT patients (n = 172 18 years) with B-ALL or B-NHL, treated with anti-CD19 CAR T-cells (tisagenlecleucel n = 184, brexucabtagene autoleucel n = 43 and axicabtagene ciloleucel n = 30), between 2018 and 2022. Three patients developed aGvHD, whereas 6 patients developed cGvHD after CAR T-cell. The 100-day cumulative incidence (CI) of new aGvHD was 1.

6% and the 12-month CI of new cGvHD was 2. 8%. The 1-year GvHD relapse-free survival and non-relapse mortality were 52. 1% and 4. 7%, respectively. Last, with a median follow up of 18. 8 months, the 1-year overall survival was 76. 8%. In summary, the GvHD rate in allo-HCT patients treated with CAR T-cell therapy is relatively low.

Our data support the view that GvHD is not a major safety issue in this setting.