CD81 通过阻断 CD274/PD-L1 的选择性自噬降解驱动放射抵抗性胶质母细胞瘤的免疫逃逸
CD81 drives immune evasion in radioresistant glioblastoma by blocking selective autophagic degradation of CD274/PD-L1.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
用新兴治疗策略重新定义肿瘤微环境
英文原题：Redefining the tumor microenvironment with emerging therapeutic strategies.
查看英文原题
Redefining the tumor microenvironment with emerging therapeutic strategies.
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中文摘要
肿瘤周围的环境，即肿瘤微环境（TME），在癌症进展和治疗反应中发挥作用。它为改进癌症治疗既带来了挑战，也带来了机遇。近年来在理解TME复杂性和多样性方面的进展，促成了治疗癌症的方法。本视角讨论了靶向TME的策略，例如利用细胞外囊泡调整网络以递送药物，以及通过联合治疗增强免疫检查点抑制剂（ICIS）。此外，它还强调了过继性细胞转移（ACT）疗法作为肿瘤治疗的一种选择。通过研究TME各组分如何相互作用，并利用单细胞RNA测序和空间转录组学等技术，我们可以开发出更精确、更有效的癌症治疗方法。本文强调需要重塑TME以增强抗肿瘤免疫并克服治疗耐药性，为精准肿瘤学的研究和临床实践提供指导。
展开英文摘要原文
The environment surrounding a tumor, known as the tumor microenvironment (TME), plays a role in how cancer progresses and responds to treatment. It poses both challenges and opportunities for improving cancer therapy. Recent progress in understanding the TME complexity and diversity has led to approaches for treating cancer. This perspective discusses the strategies for targeting the TME, such as adjusting networks using extracellular vesicles to deliver drugs and enhancing immune checkpoint inhibitors (ICIS) through combined treatments.
Furthermore, it highlights adoptive cell transfer (ACT) therapies as an option for tumors. By studying how components of the TME interact and utilizing technologies like single-cell RNA sequencing and spatial transcriptomics, we can develop more precise and efficient treatments for cancer. This article emphasizes the need to reshape the TME to boost antitumor immunity and overcome resistance to therapy, providing guidance for research and clinical practices in precision oncology.
论文信息
- 作者
- Xu S、Li X、Ma W
- 第一作者单位
- Department of Dermatology, The First Affiliated Hospital of Ningbo University, Ningbo, 315010, China.China
- 通讯作者单位
- Department of Medicine, Sanford Stem Cell Institute and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.United States
- 文献类型
- 综述
- 期刊
- Oncology research2024
- 原文标识
- PubMed 39449800 · DOI 10.32604/or.2024.055161
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