工程化益生菌用于肿瘤靶向联合化学免疫治疗
Engineered probiotics for tumor-targeted combination chemoimmunotherapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
肿瘤免疫治疗中产生 IL-9 的 T 细胞的功能多样性与调控
英文原题：Functional diversity and regulation of IL-9-producing T cells in cancer immunotherapy.
查看英文原题
Functional diversity and regulation of IL-9-producing T cells in cancer immunotherapy.
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中文摘要
产生 IL-9 的 T 细胞（T9）可调节影响多种细胞生物学过程的免疫应答，但其确切功能尚未完全阐明。既往研究已将 T9 细胞与过敏性疾病、寄生虫感染清除和多种癌症联系起来。尽管 IL-9 和 T9 细胞在癌症发生中的功能异质性已有记载，这些细胞仍为实体瘤治疗提供有前景的机会。本综述强调 IL-9 和 T9 细胞在癌症进展及治疗应答中的作用，重点关注小鼠肿瘤与癌症患者之间 IL-9/IL-9R 信号可能存在的差异。此外，我们讨论肿瘤特异性 Th9/Tc9 细胞分化的调控、这些细胞的治疗潜力，以及增强其抗肿瘤活性的现有策略。
展开英文摘要原文
IL-9-producing T cells (T9) regulate immunological responses that affect various cellular biological processes, though their precise function remains fully understood. Previous studies have linked T9 cells to conditions such as allergic disorders, parasitic infection clearance, and various types of cancers.
While the functional heterogeneity of IL-9 and T9 cells in cancer development has been documented, these cells present promising therapeutic opportunities for treating solid tumors. This review highlights the roles of IL-9 and T9 cells in cancer progression and treatment responses, focusing on potential discrepancies in IL-9/IL-9R signaling between murine tumors and cancer patients.
Additionally, we discuss the regulation of tumor-specific Th9/Tc9 cell differentiation, the therapeutic potential of these cells, and current strategies to enhance their anti-tumor activities.
论文信息
- 作者
- Kalim M、Jing R、Guo W、Xing H、Lu Y
- 第一作者单位
- Houston Methodist Cancer Center/Weill Cornell Medicine, Houston, TX, 77030, USA.United States
- 通讯作者单位
- Houston Methodist Cancer Center/Weill Cornell Medicine, Houston, TX, 77030, USA. Electronic address: ylu2@houstonmethodist.org.United States
- 文献类型
- 综述
- 期刊
- Cancer letters2024 Dec 1
- 原文标识
- PubMed 39426662 · DOI 10.1016/j.canlet.2024.217306
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