CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
肿瘤内 B 细胞的泛癌单细胞 RNA-seq 图谱
英文原题：A pan-cancer single-cell RNA-seq atlas of intratumoral B cells.
查看英文原题
A pan-cancer single-cell RNA-seq atlas of intratumoral B cells.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
肿瘤浸润性B细胞在肿瘤的发生、发展和预后中发挥重要作用，但目前缺乏一个全面的分类系统。为填补这一空白，我们呈现了一个泛癌种单细胞RNA测序（scRNA-seq）图谱，涵盖大规模样本队列中的肿瘤浸润性B细胞和浆细胞。我们识别了关键的B细胞亚群特征，揭示了不同的亚群，并突出了这些细胞在肿瘤微环境中的异质性和功能多样性。我们探索了B细胞亚群与检查点抑制剂治疗反应之间的关联，发现亚群特异性对总体反应的影响。此外，我们研究了B细胞和T细胞之间的串扰，识别了特定B细胞亚群独有的配体-受体对，并进行了空间验证。这一全面的数据集作为宝贵资源，提供了一个详细的图谱，增强了对肿瘤中B细胞复杂性的理解，并为研究和治疗策略开辟了新途径。
展开英文摘要原文
Tumor-infiltrating B cells play a significant role in tumor development, progression, and prognosis, yet a comprehensive classification system is lacking. To address this gap, we present a pan-cancer single-cell RNA sequencing (scRNA-seq) atlas of tumor-infiltrating B and plasma cells across a large sample cohort.
We identify key B cell subset signatures, revealing distinct subpopulations and highlighting the heterogeneity and functional diversity of these cells in the tumor microenvironment.
We explore associations between B cell subsets and checkpoint inhibitor therapy responses, finding subset-specific effects on overall response.
Additionally, we examine B and T cell crosstalk, identifying unique ligand-receptor pairs for specific B cell subsets, spatially validated. This comprehensive dataset serves as a valuable resource, providing a detailed atlas that enhances the understanding of B cell complexity in tumors and opens new avenues for research and therapeutic strategies.
论文信息
- 作者
- Fitzsimons E、Qian D、Enica A、Thakkar K、Augustine M、Gamble S、Reading JL、Litchfield K
- 第一作者单位
- Tumor Immunogenomics and Immunosurveillance Laboratory, University College London Cancer Institute, Paul O'Gorman, Building, 72 Huntley Street, London WC1E 6BT, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman, Building, 72 Huntley Street, London WC1E 6BT, UK; Pre-Cancer Immunology Laboratory, University College London Cancer Institute, Paul O'Gorman, Building, 72 Huntley Street, London WC1E 6BT, UK.United Kingdom
- 通讯作者单位
- Tumor Immunogenomics and Immunosurveillance Laboratory, University College London Cancer Institute, Paul O'Gorman, Building, 72 Huntley Street, London WC1E 6BT, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman, Building, 72 Huntley Street, London WC1E 6BT, UK. Electronic address: k.litchfield@ucl.ac.uk.United Kingdom
- 期刊
- Cancer cell2024 Oct 14
- 原文标识
- PubMed 39406187 · DOI 10.1016/j.ccell.2024.09.011