胃癌全身治疗中新兴的 Claudin18.2 靶向治疗：于危险中寻求高贵

Gastric cancer in advanced stages lacked effective treatment options. claudin18. 2 (CLDN18. 2) is a membrane protein that is crucial for close junctions in the differentiated epithelial cells of the gastric mucosa, playing a vital role in barrier function, and can be hardly recognized by immune cells due to its polarity pattern. As the polarity of gastric tumor cells changes, claudin18.

2 is exposed on the cell surface, resulting in immune system recognition, and making it an ideal target. In this review, we summarized the expression regulation mechanism of claudin18. 2 both in normal cells and malignant tumor cells. Besides, we analyzed the available clinical results and potential areas for future research on claudin18. 2-positive gastric cancer and claudin18. 2-targeting therapy.

In conclusion, claudin18. 2 is an ideal target for gastric cancer treatment, and the claudin18. 2-targeting therapy has changed the treatment pattern of gastric cancer.