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原发性肺结外鼻型 NK/T 细胞淋巴瘤表现为右下叶肺炎:一例病例报告

英文原题:Primary pulmonary extranodal natural killer/T-cell lymphoma of nasal type presenting as pneumonia in the right lower lobe: A case report.

查看英文原题

Primary pulmonary extranodal natural killer/T-cell lymphoma of nasal type presenting as pneumonia in the right lower lobe: A case report.

PubMed 2024/09/17(内容时间) Respir Med Case Rep Q4 · IF 0.7(JCR 2025)

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中文摘要

结外NK/T细胞淋巴瘤鼻型(EN-NK/T-CL-NT)是一种罕见的非霍奇金淋巴瘤,病变通常位于上呼吸道,如鼻腔、腭部和鼻咽部。

此外,EN-NK/T-CL-NT的原发灶极少可起源于鼻外部位,如皮肤、胃肠道、睾丸、中枢神经系统和肺部。我们描述了一位82岁男性吸烟者,因发热、咳嗽、咳痰、胸痛和胸闷8个月被送至医院。胸部计算机断层扫描(CT)显示右肺下叶胸膜下高密度影,边界不清,周围有斑片状磨玻璃影。最初,患者右肺下叶病变在接受抗炎治疗后进展。他随后接受了两次计算机断层扫描(CT)引导下的经皮经胸针吸活检和一次支气管镜检查,但未发现肿瘤细胞。通过多学科团队讨论,患者随后被转至心胸外科接受右肺下叶切除术。最终,手术标本的病理学检查证实为结外自然杀伤/T细胞淋巴瘤(ENKTCL)鼻型。由于在诊断和治疗时未发现肺外部位的证据,因此诊断为原发性肺ENKTCL。

在此我们报告一例表现为右肺下叶肺炎的原发性肺结外自然杀伤/T细胞淋巴瘤鼻型病例,并增进对该疾病的认识。

展开英文摘要原文

Extranodal Natural Killer/T Cell Lymphoma Nasal Type (EN-NK/T-CL-NT) is a rare type of non-Hodgkin lymphoma in which the lesion is usually located in the upper respiratory tract, such as nasal cavity, palate, and nasopharynx.

In addition, the primary lesion of EN-NK/T-CL-NT can rarely originate in extranasal sites such as the skin, gastrointestinal tract, testicles, central nervous system, and lungs.

We describe an 82-year-old male smoker was brought to the hospital with 8 months of fever, cough, sputum production, chest pain, and chest tightness. Computed tomography (CT) of the chest showed subpleural high-density shadow in the lower lobe of the right lung with unclear borders and surrounding patchy ground-glass shadow.

Initially, the patient's right lower lobe lesion progressed after receiving anti-inflammatory treatment. He subsequently underwent two computerized tomography (CT)-guided percutaneous transthoracic needle aspiration biopsies and a bronchoscopy, but no tumor cells were found. Through multidisciplinary team discussions, the patient was then transferred to the department of cardiothoracic surgery for right lower lobectomy.

Finally, extranodal natural killer/T-cell lymphoma (ENKTCL), nasal type, was confirmed by pathology of the surgical specimen. The diagnosis of primary pulmonary ENKTCL was made because no evidence other than extrapulmonary site was found at the time of diagnosis and treatment.

Here we report a case of primary pulmonary extranodal natural killer/T-cell lymphoma of nasal type presenting as pneumonia in the right lower lobe and enhance the understanding of the disease.

论文信息

作者
Li X、Zhu Y、Yu T、Cao L、Sun A、Hu Z
单位
Department of Thoracic Oncology, Hefei Cancer Hospital, Chinese Academy of Sciences, No. 68 Yangqiao Road, Hefei, 230000, China.China
文献类型
病例报告
期刊
Respiratory medicine case reports2024
原文标识
PubMed 39345928 · DOI 10.1016/j.rmcr.2024.102114