CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：CAR T-cell therapy in cancer: Integrating nursing perspectives for enhanced patient care.
CAR T-cell therapy in cancer: Integrating nursing perspectives for enhanced patient care.
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嵌合抗原受体（CAR）T细胞疗法代表了癌症治疗的重大进展，尤其是对血液系统恶性肿瘤。目前正在探索多种癌症免疫治疗策略，包括细胞因子、癌症疫苗、免疫检查点抑制剂、免疫调节剂单克隆抗体等。该疗法在治疗急性淋巴细胞白血病（ALL）、弥漫性大B细胞淋巴瘤（DLBCL）和多发性骨髓瘤等疾病方面已显示出令人瞩目的疗效，常使难治性病例达到完全缓解。然而，CAR-T 细胞疗法的临床应用也伴随着挑战，尤其是严重的副作用。有效管理这些不良反应需要细致的监测和及时干预，凸显了护理在这一治疗过程中的关键作用。护士在患者教育、监测、症状管理、护理协调和心理社会支持方面发挥着至关重要的作用，确保治疗安全有效。随着研究的进展和新型CAR-T 细胞疗法的开发，护理专业人员在优化患者结局方面仍然至关重要。CAR-T 细胞疗法的持续演进有望改善结局，而护理专业人员是其成功不可或缺的一部分。
Chimeric antigen receptor (CAR) T-cell therapy represents a significant advancement in cancer treatment, particularly for hematologic malignancies. Various cancer immunotherapy strategies are presently being explored, including cytokines, cancer vaccines, immune checkpoint inhibitors, immunomodulators monoclonal antibodies, etc. The therapy has shown impressive efficacy in treating conditions such as acute lymphoblastic leukemia (ALL), diffuse large B-cell lymphoma (DLBCL), and multiple myeloma, often leading to complete remission in refractory cases.
However, the clinical application of CAR T-cell therapy is accompanied by challenges, notably severe side effects. Effective management of these adverse effects requires meticulous monitoring and prompt intervention, highlighting the critical role of nursing in this therapeutic process.
Nurses play a crucial role in patient education, monitoring, symptom management, care coordination, and psychosocial support, ensuring safe and effective treatment. As research advances and new CAR T-cell therapies are developed, the role of nursing professionals remains pivotal in optimizing patient outcomes. The continued evolution of CAR T-cell therapy promises improved outcomes, with nursing professionals integral to its success.
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →
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