CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
从前景到进展：胶质母细胞瘤免疫治疗的动态格局
英文原题：From promise to progress: the dynamic landscape of glioblastoma immunotherapy.
查看英文原题
From promise to progress: the dynamic landscape of glioblastoma immunotherapy.
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中文摘要
多形性胶质母细胞瘤（GBM）是最常见的中枢神经系统癌症，尽管有多种有效的治疗手段：强化细胞毒性治疗、嵌合抗原受体（CAR）-T 细胞治疗、病毒治疗、过继细胞治疗、免疫检查点阻断治疗、放射治疗和疫苗治疗，但其生存率仍然很低。本综述探讨了免疫靶向的基本概念，并审查了检查点阻断药物、CAR-T 细胞、溶瘤病毒、联合多模式免疫治疗和癌症疫苗等产品。基于对这些策略的最新研究、正在进行的临床试验的发现以及既往试验结果，讨论了克服 GBM 治疗当前限制和挑战的新方法。
展开英文摘要原文
Glioblastoma multiforme (GBM) is the most common CNS cancer, it has dismal survival rates despite several effective mediators: intensified cytotoxic therapy, chimeric antigen receptor (CAR)-T cell therapy, viral therapy, adoptive cell therapy, immune checkpoint blockade therapy, radiation therapy and vaccine therapy.
This review examines the basic concepts underlying immune targeting and examines products such as checkpoint blockade drugs, CAR-T cells, oncolytic viruses, combinatory multimodal immunotherapy and cancer vaccines. New approaches to overcoming current constraints and challenges in GBM therapy are discussed, based on recent studies into these tactics, findings from ongoing clinical trials, as well as previous trial results.
论文信息
- 作者
- Ijaz M、Ullah Z、Aslam B、Khurshid M、Chen P、Guo B
- 第一作者单位
- School of Science, Shenzhen Key Laboratory of Flexible Printed Electronics Technology, Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive Application, Harbin Institute of Technology, Shenzhen 518055, China; Institute of Microbiology, Government College University Faisalabad, Pakistan.China
- 通讯作者单位
- School of Science, Shenzhen Key Laboratory of Flexible Printed Electronics Technology, Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive Application, Harbin Institute of Technology, Shenzhen 518055, China. Electronic address: guobing2020@hit.edu.cn.China
- 文献类型
- 综述
- 期刊
- Drug discovery today2024 Nov
- 原文标识
- PubMed 39307298 · DOI 10.1016/j.drudis.2024.104188