肿瘤细胞治疗研究
英文原题：Natural killer cells in neuroblastoma: immunological insights and therapeutic perspectives.
自然杀伤（NK）细胞在复杂的肿瘤微环境中具有多方面的作用。
自然杀伤（NK）细胞在复杂的肿瘤微环境中具有多方面的作用。它们是固有免疫的关键组成部分，并塑造肿瘤-免疫细胞相互作用的动态格局，因此可用于治疗干预。基于NK的免疫疗法在血液系统恶性肿瘤中取得了显著成功，但这些疗法在实体瘤中面临许多挑战，包括神经母细胞瘤（NB），这是一种起源于交感神经系统的儿童肿瘤。本综述以NB为重点，概述NK细胞识别和清除恶性细胞所采用的机制，深入探讨配体-受体相互作用、细胞因子和其他分子之间促进NK与NB细胞交互对话的动态关系。我们讨论NK细胞的免疫调节功能以及在NB中导致这种免疫监视缺失的机制，并重点关注这一动态如何在NB近期的免疫治疗进展中被利用。
Natural killer (NK) cells have multifaceted roles within the complex tumor milieu. They are pivotal components of innate immunity and shape the dynamic landscape of tumor-immune cell interactions, and thus can be leveraged for use in therapeutic interventions. NK-based immunotherapies have had remarkable success in hematological malignancies, but these therapies are met with many challenges in solid tumors, including neuroblastoma (NB), a childhood tumor arising from the sympathetic nervous system. With a focus on NB, this review outlines the mechanisms employed by NK cells to recognize and eliminate malignant cells, delving into the dynamic relationship between ligand-receptor interactions, cytokines, and other molecules that facilitate the cross talk between NK and NB cells. We discuss the immunomodulatory functions of NK cells and the mechanisms that contribute to loss of this immunosurveillance in NB, with a focus on how this dynamic has been utilized in recent immunotherapy advancements for NB.
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