CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
肿瘤浸润 B 细胞：其在肿瘤微环境中的双重机制作用
英文原题：Tumor-infiltrating B cells: Their dual mechanistic roles in the tumor microenvironment.
查看英文原题
Tumor-infiltrating B cells: Their dual mechanistic roles in the tumor microenvironment.
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中文摘要
肿瘤的发生与发展同免疫系统结构和功能的异常密切相关，肿瘤免疫治疗与肿瘤微环境（TME）有着千丝万缕的联系。早期对TME中淋巴细胞的研究主要集中在T细胞上。然而，随着研究的深入，肿瘤浸润性B细胞（TIL-Bs）在肿瘤免疫中的多重作用，包括抗肿瘤和促肿瘤效应，日益受到关注。本文探讨了TME的组成及TIL-Bs的生物学特征，研究了其在TME中的双重作用，以期为肿瘤免疫治疗提供新的见解和策略。
展开英文摘要原文
The occurrence and development of tumors are closely associated with abnormalities in the immune system's structure and function, with tumor immunotherapy being intricately linked to the tumor microenvironment (TME). Early studies on lymphocytes within the TME primarily concentrated on T cells.
However, as research has advanced, the multifaceted roles of tumor-infiltrating B cells (TIL-Bs) in tumor immunity, encompassing both anti-tumor and pro-tumor effects, have garnered increasing attention. This paper explored the composition of the TME and the biological characteristics of TIL-Bs, investigating the dual roles within the TME to offer new insights and strategies for tumor immunotherapy.
论文信息
- 作者
- Xue D、Hu S、Zheng R、Luo H、Ren X
- 第一作者单位
- School of Chinese Classics, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.China
- 通讯作者单位
- Department of Oncology II, Southern Medical University Hospital of Integrated Traditional Chinese and Western Medicine, Southern Medical University, Guangzhou 510515, China. Electronic address: 49552851@qq.com.China
- 文献类型
- 综述
- 期刊
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2024 Oct
- 原文标识
- PubMed 39270540 · DOI 10.1016/j.biopha.2024.117436