工程化益生菌用于肿瘤靶向联合化学免疫治疗
Engineered probiotics for tumor-targeted combination chemoimmunotherapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
磁性纳米颗粒在癌症过继性细胞治疗中的应用；细胞的训练、引导与成像
英文原题：Application of magnetic nanoparticles in adoptive cell therapy of cancer; training, guiding and imaging cells.
查看英文原题
Application of magnetic nanoparticles in adoptive cell therapy of cancer; training, guiding and imaging cells.
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中文摘要
过继性细胞治疗（ACT）作为癌症的一种令人振奋的治疗方案即将成为现实。然而，ACT 的广泛应用往往受到若干挑战的限制，包括肿瘤特异性 T 细胞引发的复杂性以及实体瘤中较差的浸润能力。纳米技术与癌症免疫治疗的融合正日趋成熟，有望解决 ACT 的局限性。近期研究已提供证据表明，磁性纳米颗粒（MNPs）可用于生成智能免疫细胞，并规避与传统 ACT 相关的问题。在此，我们综述了 MNPs 在癌症 ACT 中用于改进免疫细胞的制备、引导和追踪方面的当前进展。此外，我们还评述了未来面临的挑战以及优化 MNPs 以适用于临床环境的策略。[框：见正文]。
展开英文摘要原文
Adoptive cell therapy (ACT) is on the horizon as a thrilling therapeutic plan for cancer.
However, widespread application of ACT is often restricted by several challenges, including complexity of priming tumor-specific T cells and poor trafficking in solid tumors. The convergence of nanotechnology and cancer immunotherapy is coming of age and could address the limitations of ACT. Recent studies have provided evidence on the application of magnetic nanoparticles (MNPs) to generate smart immune cells and to bypass problems associated with conventional ACT.
Herein, we review current progress in the application of MNPs to improve preparing, guiding and tracking immune cells in cancer ACT. Besides, we comment on the challenges ahead and strategies to optimize MNPs for clinical settings. [Box: see text].
论文信息
- 作者
- Mohammadi V、Esmaeilzadeh K、Esmaeilzadeh A
- 第一作者单位
- Student Research Committee, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.Iran
- 通讯作者单位
- Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.Iran
- 文献类型
- 综述
- 期刊
- Nanomedicine (London, England)2024
- 原文标识
- PubMed 39258568 · DOI 10.1080/17435889.2024.2395239
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