CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
重新审视嵌合抗原受体（CAR）T 细胞治疗时代造血干细胞移植在复发大 B 细胞淋巴瘤中的作用
英文原题：Re-examining the role of hematopoietic stem cell transplantation in relapsed large B-cell lymphoma in the era of chimeric antigen receptor (CAR) T-cell therapy.
查看英文原题
Re-examining the role of hematopoietic stem cell transplantation in relapsed large B-cell lymphoma in the era of chimeric antigen receptor (CAR) T-cell therapy.
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中文摘要
历史上，挽救性化学免疫治疗联合巩固性自体造血干细胞移植（ASCT）是复发/难治性大B细胞淋巴瘤（LBCL）患者唯一可能治愈的治疗选择。对于挽救性化疗/ASCT治疗无应答的淋巴瘤患者以及不适合ASCT的患者，治疗选择很少且预后较差。嵌合抗原受体（CAR）T细胞疗法获批用于复发/难治性LBCL，以其前所未有的缓解率和缓解持久性彻底改变了治疗格局。因此，CAR-T 细胞疗法的早期干预已被探索，对CAR-T 细胞疗法的热情已使ASCT黯然失色。在本文中，我们将回顾ASCT和CAR-T 细胞疗法在复发LBCL中可用的数据，并探讨在CAR-T 细胞疗法时代ASCT在复发/难治性LBCL中的作用。
展开英文摘要原文
Historically, salvage chemoimmunotherapy with consolidative autologous hematopoietic stem cell transplantation (ASCT) was the only potentially curative therapeutic option for patients with relapsed/refractory large B-cell lymphoma (LBCL). Treatment options were few and outcomes poor for patients whose lymphoma failed to respond to salvage chemotherapy/ASCT and for patients not eligible for ASCT.
The approval of chimeric antigen receptor (CAR) T-cell therapy for relapsed/refractory LBCL revolutionized the treatment landscape with unprecedented response rates and durability of responses. As a result, earlier intervention with CAR T-cell therapy has been explored, and the enthusiasm for CAR T-cell therapy has overshadowed ASCT. In this article, we will review the data available for ASCT and CAR T-cell therapy in relapsed LBCL and will examine the role for ASCT in relapsed/refractory LBCL in the era of CAR T-cell therapy.
论文信息
- 作者
- Moyo TK、Vaidya R
- 第一作者单位
- Department of Hematologic Oncology and Blood Disorders, Atrium Health Levine Cancer Institute, Charlotte, NC, United States.United States
- 通讯作者单位
- Department of Hematology and Oncology, Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston Salem, NC, United States.United States
- 文献类型
- 综述
- 期刊
- Frontiers in oncology2024
- 原文标识
- PubMed 39211553 · DOI 10.3389/fonc.2024.1397186
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