CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Role of TIM-3 in ovarian cancer: the forsaken cop or a new noble.
Role of TIM-3 in ovarian cancer: the forsaken cop or a new noble.
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T细胞免疫球蛋白和黏蛋白结构域-3（TIM-3）是继PD1和CTLA4之后的重要免疫检查点，广泛存在于多种免疫细胞中。然而，其在近期临床试验中的表现似乎令人失望。卵巢癌（OC）是妇科死亡率较高的恶性肿瘤，在免疫治疗方面面临重大障碍。TIM-3的广泛存在为OC的免疫治疗提供了新机遇。本研究综述了TIM-3在OC中的作用，并评估其作为免疫治疗靶点的潜力。讨论了TIM-3对OC免疫微环境的调控作用，重点关注证明TIM-3在OC中调节多种免疫细胞的临床前研究。此外，还探讨了在OC中靶向TIM-3的潜在治疗优势和挑战。
T cell immunoglobulin and mucin domain-3 (TIM-3), a crucial immune checkpoint following PD1 and CTLA4, is widely found in several immune cells. Nonetheless, its performance in recent clinical trials appears disappointing. Ovarian cancer (OC), a malignant tumor with a high mortality rate in gynecology, faces significant hurdles in immunotherapy. The broad presence of TIM-3 offers a new opportunity for immunotherapy in OC.
This study reviews the role of TIM-3 in OC and assesses its potential as a target for immunotherapy. The regulatory effects of TIM-3 on the immune microenvironment in OC are discussed, with a focus on preclinical studies that demonstrate TIM-3's modulation of various immune cells in OC.
Additionally, the potential therapeutic advantages and challenges of targeting TIM-3 in OC are examined.
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