CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 治疗后两例 B 细胞恶性肿瘤中谱系定义抗原完全丢失
英文原题：Complete loss of lineage defining antigens in two cases of B-cell malignancies following CAR-T therapy.
查看英文原题
Complete loss of lineage defining antigens in two cases of B-cell malignancies following CAR-T therapy.
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中文摘要
靶向免疫治疗是治疗高危和难治/复发性淋巴系统恶性肿瘤的一种有前景的方法。尽管该策略在治疗非霍奇金B细胞淋巴瘤和浆细胞骨髓瘤方面已取得显著成功，但仍可能发生靶抗原丢失的复发。少数情况下，可发生多个谱系特异性标记的完全丢失。我们描述2例B细胞肿瘤病例，并附有相关的免疫组化、细胞遗传学和分子学结果。在接受靶向CAR-T 治疗后，这两例病例——一例为侵袭性B细胞淋巴瘤，另一例为浆细胞骨髓瘤——分别丢失了B细胞和浆细胞抗原。靶向治疗后谱系特异性标记的完全丢失是一种罕见事件，使复发肿瘤的诊断具有挑战性。在本文中，我们还回顾了文献，并强调了靶向治疗后抗原丢失的可能机制。
展开英文摘要原文
Targeted immunotherapy is a promising approach in treating high-risk and refractory/relapsed lymphoid malignancies. Although this strategy has shown a significant success in treating non-Hodgkin B-cell lymphomas and plasma cell myeloma, relapse with loss of targeted antigen can occur. Rarely, complete loss of multiple lineage specific markers can happen.
We are describing 2 cases of B-cell neoplasms along with contributing immunohistochemistry, cytogenetic, and molecular results. Post-targeted CAR-T therapy, both cases, one aggressive B-cell lymphoma and the other plasma cell myeloma, lost B-cell, and plasma cell antigens, respectively. Complete loss of lineage specific markers post-targeted therapy is a rare event that makes the diagnosis of the relapsed neoplasm challenging. In this article, we also reviewed the literature and highlighted possible mechanisms of antigen loss following targeted therapy.
论文信息
- 作者
- Torabi A、Love J、Hyun T、Pham A、Gauthier J、Hirayama A、Wu D、Naresh K
- 单位
- Department of Laboratory Medicine and Pathology, University of Washington, Seattle 1959 NE Pacific Street, Box 357110, Seattle, WA, 98195, USA. alirezat@uw.edu.United States
- 文献类型
- 病例报告 · 综述
- 期刊
- Journal of hematopathology2024 Dec
- 原文标识
- PubMed 39186243 · DOI 10.1007/s12308-024-00602-w