CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
释放潜力：靶向肿瘤微环境中的代谢途径用于癌症治疗
英文原题：Unlocking the potential: Targeting metabolic pathways in the tumor microenvironment for Cancer therapy.
查看英文原题
Unlocking the potential: Targeting metabolic pathways in the tumor microenvironment for Cancer therapy.
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中文摘要
癌症发病率和死亡率不断上升，并影响着全球预期寿命。肿瘤微环境（TME）中的代谢重编程与肿瘤发生、进展、转移和耐药密切相关。肿瘤细胞通过细胞因子和代谢物的代谢诱导以及代谢底物竞争，驱动TME中其他细胞的代谢重编程。因此，这通过提供代谢支持以及促进免疫抑制和血管生成来促进肿瘤细胞生长。TME中的代谢相互作用提供了潜在的治疗靶点。在此，我们聚焦于TME中四种主要细胞亚群的代谢重编程：CAFs、TAMs、TILs和TECs，以及它们与肿瘤细胞的相互作用。我们还总结了针对这些细胞代谢途径的药物和疗法，尤其是在免疫检查点阻断治疗的背景下。
展开英文摘要原文
Cancer incidence and mortality are increasing and impacting global life expectancy. Metabolic reprogramming in the tumor microenvironment (TME) is intimately related to tumorigenesis, progression, metastasis and drug resistance.
Tumor cells drive metabolic reprogramming of other cells in the TME through metabolic induction of cytokines and metabolites, and metabolic substrate competition. Consequently, this boosts tumor cell growth by providing metabolic support and facilitating immunosuppression and angiogenesis. The metabolic interplay in the TME presents potential therapeutic targets.
Here, we focus on the metabolic reprogramming of four principal cell subsets in the TME: CAFs, TAMs, TILs and TECs, and their interaction with tumor cells.
We also summarize medications and therapies targeting these cells' metabolic pathways, particularly in the context of immune checkpoint blockade therapy.
论文信息
- 作者
- Jia S、Bode AM、Chen X、Luo X
- 第一作者单位
- Hunan Key Laboratory of Oncotarget Gene, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, PR China; Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, Hunan 410078, PR China.China
- 通讯作者单位
- Hunan Key Laboratory of Oncotarget Gene, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, PR China; Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, Hunan 410078, PR China; Key Laboratory of Biological Nanotechnology of National Health Commission, Central South University, Changsha, Hunan 410078, China. Electronic address: luocsu@csu.edu.cn.China
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Biochimica et biophysica acta. Reviews on cancer2024 Sep
- 原文标识
- PubMed 39111710 · DOI 10.1016/j.bbcan.2024.189166