肿瘤细胞治疗研究
英文原题：Current mRNA-based vaccine strategies for glioma treatment.
Current mRNA-based vaccine strategies for glioma treatment.
胶质瘤是最具侵袭性的脑肿瘤类型之一，与高发病率和高死亡率相关。
胶质瘤是最具侵袭性的脑肿瘤类型之一，与高发病率和死亡率相关。目前，胶质瘤的常规治疗如手术切除、放疗和化疗效果有限，需要新的方法来改善患者预后。基于mRNA的疫苗是癌症治疗（包括胶质瘤）的一种有前景的治疗策略。近年来，使用基于mRNA的树突状细胞疫苗的免疫治疗在临床前和临床试验中显示出巨大潜力。树突状细胞是专业的抗原呈递细胞，在启动和调节免疫反应中起着至关重要的作用。在这篇综述中，我们总结了基于mRNA的疫苗用于胶质瘤的当前进展，重点关注基于树突状细胞的mRNA疫苗的最新进展。我们还讨论了基于mRNA的临床应用用于胶质瘤的可行性和安全性。
Gliomas are one of the most aggressive types of brain tumors and are associated with high morbidity and mortality rates. Currently, conventional treatments for gliomas such as surgical resection, radiotherapy, and chemotherapy have limited effectiveness, and new approaches are needed to improve patient outcomes. mRNA-based vaccines represent a promising therapeutic strategy for cancer treatment, including gliomas. Recent advances in immunotherapy using mRNA-based dendritic cell vaccines have shown great potential in preclinical and clinical trials. Dendritic cells are professional antigen-presenting cells that play a crucial role in initiating and regulating immune responses. In this review, we summarize the current progress of mRNA-based vaccines for gliomas, with a focus on recent advances in dendritic cell-based mRNA vaccines. We also discuss the feasibility and safety of mRNA-based clinical applications for gliomas.
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