老年患者中的抗 CD19 CAR-T 细胞治疗：来自 GETH-TC/GELTAMO 的多中心真实世界经验

Chimeric antigen receptor (CAR)-T cell therapy is approved for the treatment of relapsed/refractory (R/R) large B cell lymphoma (LBCL).

However, elderly patients might not be candidates for this therapy due to its toxicity, and criteria for candidate selection are lacking.

Our aim was to analyze efficacy and toxicity results of CAR-T cell therapy in the population of patients 70 years and older as compared to those obtained in younger patients in the real-world setting. A multicentric retrospective study was performed including patients with R/R aggressive LBCL who received commercial CAR-T cell therapy with either tisagenlecleucel or axicabtagene ciloleucel within the Spanish Group of Hematopoietic Transplant and Cell Therapy/Spanish Group of Lymphomas and Autologous Transplant (GETH-TC/GELTAMO) centers between 2019 and 2023. As of August 2023, 442 adult patients with aggressive LBCL underwent apheresis for CAR-T cell therapy as third or subsequent line and follow-up data was collected. Of 412 infused patients, 71 (17%) were 70 years or older. Baseline characteristics, product selection, and characteristics at apheresis (including disease status, Ann Arbor stage, revised international prognosis index (R-IPI), bulky disease, lactate dehydrogenase [LDH] and ECOG [Eastern Cooperative Group performance status]) were comparable between groups. Median time from both approval to infusion and apheresis to infusion did not differ.

No differences were found between groups in overall and complete response rates at 1 and 3 months. With a median follow-up of 12. 2 months (range 1-44), 12-month progression-free survival (PFS) and overall survival (OS) were comparable between groups (35. 2% in <70 years vs. 35. 9% in 70 years (P = . 938) and 51. 1% and 52. 1% (P = . 885), respectively). Age 70 years did not affect PFS (hazard ratio (HR) 0. 98, P = . 941) and OS (HR 0. 97, P = . 890) in the univariate and multivariate analysis. Cytokine release syndrome (CRS) was observed in 82% of patients <70 years old and 84. 5% in 70 years old (P = . 408).

Grade 3 CRS was more frequent in the older group (5% vs. 15%, P = . 002). In the multivariate analysis, age 70 years was associated with an increased risk of grade 3 CRS (OR 3. 7, P = . 013). No differences were observed in terms of overall neurotoxicity (35% vs. 42%, P = . 281) or grade 3 (12% vs. 17%, P = .

33). The proportion of patients with infections, admission to the intensive care unit within the first month, and non-relapse mortality were similar between both groups. CAR-T cell therapy in patients older than 70 years showed similar efficacy to that observed in younger patients in the real-world setting.

However, age 70 years was an independent risk factor for grades 3-4 CRS. The need for additional strategies to reduce toxicity in this population should be addressed in future studies.