NHL 患者自体移植后早期免疫恢复的预测因素：一项多中心前瞻性研究

Early lymphocyte recovery as manifested by an absolute lymphocyte count at d+15 (ALC-15) ≥ 0. 5 × 10 9 /L after autologous hematopoietic stem cell transplantation (AHCT) has been associated with a better outcome. This prospective multicenter study aimed to clarify factors associated with ALC-15 ≥ 0. 5 × 10 9 /L after AHCT among 178 patients with non-Hodgkin lymphoma. The mobilization capacity, as manifested by peak blood CD34 + cell numbers > 45 × 10 6 /L correlated with higher ALC-15 levels ( p = 0. 020).

In addition, the amount of CD3 + CD4 + T cells > 31. 8 × 10 6 /kg in the infused graft predicted ALC-15 ≥ 0. 5 × 10 9 /L ( p < 0. 001). Also, the number of infused graft CD3 + CD8 + T cells > 28. 8 × 10 6 /kg ( p = 0. 017) and NK cells > 4. 4 × 10 6 /kg was linked with higher ALC-15 ( p < 0. 001). The two-year progression-free survival after AHCT was significantly better in patients with ALC-15 ≥ 0.

5 × 10 9 /L (74 vs. 57%, p = 0. 027). The five-year OS in patients with higher ALC-15 was 78% vs. 60% in those with lower ALC-15 ( p = 0. 136). To conclude, the mobilization capacity of CD34 + cells and detailed measures of graft cellular content mark prognostic tools that predict ALC-15 ≥ 0. 5 × 10 9 /L, which is associated with a better outcome in NHL patients after AHCT.