CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
结直肠癌中的肿瘤免疫微环境与 T 细胞相关免疫治疗
英文原题：The tumor immune microenvironment and T-cell-related immunotherapies in colorectal cancer.
查看英文原题
The tumor immune microenvironment and T-cell-related immunotherapies in colorectal cancer.
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中文摘要
肿瘤微环境包含多种免疫T细胞亚群，它们影响结直肠癌进展，也是免疫治疗的重要组成部分。T细胞在肿瘤内发育和迁移，识别肿瘤特异性抗原并调控免疫监视。依据不同T细胞亚群在肿瘤免疫微环境中的作用，当前免疫疗法包括细胞因子、单克隆抗体、肽疫苗和CAR-T 细胞等。本文综述结直肠癌肿瘤免疫微环境的组成、T细胞在疾病发生发展中的作用及现有T细胞相关免疫疗法。未来仍需进一步研究结直肠癌特异性肿瘤抗原、T细胞基因调控及免疫活性调节。
展开英文摘要原文
The tumor microenvironment includes a complex network of immune T-cell subsets that play important roles in colorectal cancer (CRC) progression and are key elements of CRC immunotherapy. T cells develop and migrate within tumors, recognizing tumor-specific antigens to regulate immune surveillance.
Current immunotherapies are divided into the following main categories based on the regulatory role of T-cell subsets in the tumor immune microenvironment (TIME): cytokines, monoclonal antibodies, peptide vaccines, CAR-T cells and more. This review describes the composition of the tumor immune microenvironment in colorectal cancer and the involvement of T cells in the pathogenesis and progression of CRC as well as current T-cell-related immunotherapies.
Further studies on CRC-specific tumor antigens, the gene regulation of T cells, and the regulation of immune activity are needed.
论文信息
- 作者
- Chuang L、Qifeng J、Shaolei Y
- 第一作者单位
- Hanan Branch of the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Guogoli Street, Nangang District, Harbin, China.China
- 通讯作者单位
- Hanan Branch of the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Guogoli Street, Nangang District, Harbin, China. yushaolei@hljucm.edu.cn.China
- 文献类型
- 综述
- 期刊
- Discover oncology2024 Jun 25
- 原文标识
- PubMed 38918278 · DOI 10.1007/s12672-024-01117-7
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