CD81 通过阻断 CD274/PD-L1 的选择性自噬降解驱动放射抵抗性胶质母细胞瘤的免疫逃逸
CD81 drives immune evasion in radioresistant glioblastoma by blocking selective autophagic degradation of CD274/PD-L1.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
工程化巨噬细胞及其衍生物：抗肿瘤治疗的新希望
英文原题：Engineering macrophages and their derivatives: A new hope for antitumor therapy.
查看英文原题
Engineering macrophages and their derivatives: A new hope for antitumor therapy.
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中文摘要
巨噬细胞是免疫系统的核心，几乎存在于所有组织中。近年来，基于巨噬细胞的疗法开发引起了显著关注。这些疗法利用巨噬细胞在免疫中的关键作用、其穿越生物屏障的能力以及在肿瘤中聚集的倾向。本综述探讨了基于巨噬细胞的治疗进展。我们讨论了通过生物工程改造巨噬细胞以增强抗肿瘤效果、使用 CAR 巨噬细胞疗法靶向癌细胞，以及巨噬细胞作为治疗递送载体。此外，我们还审视了工程化巨噬细胞产物，如细胞外囊泡和膜包被纳米颗粒，在精准且低毒性肿瘤治疗中的潜力。同时强调了将这些疗法从研究推向临床实践所面临的挑战。旨在简要总结工程化巨噬细胞在癌症治疗中的现状、挑战和未来方向。
展开英文摘要原文
Macrophages are central to the immune system and are found in nearly all tissues. Recently, the development of therapies based on macrophages has attracted significant interest. These therapies utilize macrophages' key roles in immunity, their ability to navigate biological barriers, and their tendency to accumulate in tumors. This review explores the advancement of macrophage-based treatments.
We discuss the bioengineering of macrophages for improved anti-tumor effects, the use of CAR macrophage therapy for targeting cancer cells, and macrophages as vehicles for therapeutic delivery.
Additionally, we examine engineered macrophage products, like extracellular vesicles and membrane-coated nanoparticles, for their potential in precise and less toxic tumor therapy. Challenges in moving these therapies from research to clinical practice are also highlighted. The aim is to succinctly summarize the current status, challenges, and future directions of engineered macrophages in cancer therapy.
论文信息
- 作者
- Wei F、Liu H、Wang Y、Li Y、Han S
- 第一作者单位
- Department of General surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang, Liaoning Province 110032, China.China
- 通讯作者单位
- Department of Cardiology, the Fourth Affiliated Hospital, China Medical University, Shenyang, Liaoning Province 110032, China. Electronic address: hans@cmu.edu.cn.China
- 文献类型
- 综述
- 期刊
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2024 Aug
- 原文标识
- PubMed 38878637 · DOI 10.1016/j.biopha.2024.116925