CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Identification of Core Techniques That Enhance Genome Editing of Human T Cells Expressing Synthetic Antigen Receptors.
Identification of Core Techniques That Enhance Genome Editing of Human T Cells Expressing Synthetic Antigen Receptors.
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近年来，基因组编辑技术取得了显著进展，能够精确调控外源和内源基因。这些进展已被广泛应用于人类T淋巴细胞的工程化改造，推动了针对癌症患者的改变临床实践的疗法的发展，并为多种非恶性疾病提供了合成免疫细胞疗法的前景。许多不同的概念和技术方法已被用于编辑T细胞基因组，然而，关于哪些技术在生产、基因编辑和转基因表达方面最为有效的针对性评估却鲜有报道。通过广泛的比较评估，我们确定了在生产的关键阶段最有效增强研究规模和临床前T细胞产品工程化的方法。
Genome editing technologies have seen remarkable progress in recent years, enabling precise regulation of exogenous and endogenous genes. These advances have been extensively applied to the engineering of human T lymphocytes, leading to the development of practice changing therapies for patients with cancer and the promise of synthetic immune cell therapies for a variety of nonmalignant diseases.
Many distinct conceptual and technical approaches have been used to edit T-cell genomes, however targeted assessments of which techniques are most effective for manufacturing, gene editing, and transgene expression are rarely reported. Through extensive comparative evaluation, we identified methods that most effectively enhance engineering of research-scale and preclinical T-cell products at critical stages of manufacturing.
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