CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
HIV 感染者的造血干细胞移植和细胞治疗
英文原题：Hematopoietic stem cell transplantation and cellular therapy in persons living with HIV.
查看英文原题
Hematopoietic stem cell transplantation and cellular therapy in persons living with HIV.
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研究思路按摘要原文分段
目的
总结干细胞移植和细胞治疗的最新研究，并阐述其对HIV感染者（PWH）、血液系统恶性肿瘤和HIV-1治愈的意义。
结果
异基因（alloSCT）和自体（autoSCT）干细胞移植已被证明无论HIV-1状态如何均具有良好的耐受性和有效性。alloSCT可使HIV-1潜伏感染储存库下降数个数量级，低于单独使用抗逆转录病毒治疗（ART）所能达到的水平。在alloSCT中使用CCR5Δ2/Δ32供者已实现HIV-1治愈。在过去12个月中，已发表了三例治愈病例，为进一步了解HIV-1控制所需的条件提供了深入见解。血液系统恶性肿瘤治疗的其他进展包括CAR-T 细胞疗法，该疗法在合并淋巴瘤的PWH中具有活性。摘要：在此我们讨论PWH合并癌症中SCT和细胞治疗的进展。此外，我们讨论这些技术如何被用于实现HIV-1治愈。
展开英文摘要原文
PURPOSE OF REVIEW: Summarize the latest research of both stem cell transplantation and cellular therapy and present the implications with respect to persons with HIV (PWH), hematologic malignancies, and HIV-1 cure. RECENT FINDINGS: Allogeneic (alloSCT) and autologous (autoSCT) stem cell transplantation have been shown to be well tolerated and effective regardless of HIV-1 status. AlloSCT leads to a decrease in the HIV-1 latently infected reservoir orders of magnitude below that achieved with antiretroviral therapy (ART) alone.
Utilization of CCR5Δ2/Δ32 donors in an alloSCT has resulted in HIV-1 cures. In the last 12 months, three cases of cure have been published, giving further insight into the conditions required for HIV-1 control. Other advances in the treatment of hematological cancers include chimeric antigen receptor T-cell (CART) therapy, which are active in PWH with lymphoma. SUMMARY: Here we discuss the advances in SCT and cellular therapy in PWH and cancer.
Additionally, we discuss how these technologies are being utilized to achieve HIV-1 cure.
论文信息
- 作者
- Rubinstein PG、Galvez C、Ambinder RF
- 第一作者单位
- Section of Hematology/Oncology, Department of Medicine, University of Illinois.United States
- 通讯作者单位
- Division of Hematologic Malignancies and Bone Marrow Transplantation, Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.United States
- 文献类型
- 综述
- 期刊
- Current opinion in infectious diseases2024 Aug 1
- 原文标识
- PubMed 38820072 · DOI 10.1097/QCO.0000000000001022