不适合移植的大 B 细胞淋巴瘤二线使用 axicabtagene ciloleucel：ALYCANTE 最终分析
Second-line axicabtagene ciloleucel in large B-cell lymphoma ineligible for transplantation: ALYCANTE final analysis.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
接受免疫治疗的弥漫大 B 细胞淋巴瘤患者中的播散性马红球菌感染
英文原题：Disseminated Rhodococcus equi infection in a patient with diffuse large B-cell lymphoma treated with immunotherapy.
查看英文原题
Disseminated Rhodococcus equi infection in a patient with diffuse large B-cell lymphoma treated with immunotherapy.
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中文摘要
免疫疗法可能导致免疫功能受损，使 Rhodococcus 等机会性病原体得以繁殖。绝大多数 Rhodococcus 感染发生于免疫功能低下者。本文描述一例弥漫性大 B 细胞淋巴瘤患者接受免疫治疗后发生播散性马红球菌感染。通过细胞形态学和组织化学检查可辅助诊断 Rhodococcus 感染，并可通过测序确认病原体。总之，对于接受免疫治疗的免疫功能低下患者发生肉芽肿性炎症时，应将 Rhodococcus 纳入鉴别诊断。
展开英文摘要原文
Immunotherapies can lead to an immune compromised state that can allow for opportunistic pathogens such as Rhodococcus to flourish. The vast majority of Rhodococcus infections occur in immunocompromised hosts.
Here we describe disseminated Rhodococcus equi infection in a patient with diffuse large B-cell lymphoma treated with immunotherapy. Infection with Rhodococcus can be diagnosed with the aid of cytomorphology and histochemical findings and the organism confirmed by sequencing.
In conclusion, Rhodococcus should be considered in the differential of granulomatous inflammation in immunocompromised individuals treated with immunotherapies.
论文信息
- 作者
- Sterner RM、Schuetz AN、Larson JM、Zomok CD、Thangaiah JJ
- 单位
- Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.United States
- 文献类型
- 病例报告
- 期刊
- IDCases2024
- 原文标识
- PubMed 38711945 · DOI 10.1016/j.idcr.2024.e01972
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