CAR-T(CAR-T)细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T(CAR-T)细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:CAR T-cell therapy and the onco-nephrologist.
CAR T-cell therapy and the onco-nephrologist.
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细胞疗法,尤其是革命性的嵌合抗原受体(CAR)T 细胞疗法,已改变肿瘤学治疗格局,并在实际治疗中取得重要进展。目前,淋巴瘤、骨髓瘤和白血病等疾病的既定指南已积极推荐使用这些曾经非常规的疗法。其临床影响源于卓越疗效,正在重塑肿瘤治疗方法和实践。然而,CAR-T 通过细胞作用和炎症反应攻击肿瘤,也会引起多种不良事件,其中包括肾损伤。因此,妥善管理这些副作用至关重要。肿瘤科医生与肾脏专科医生的知识整合,催生了新的肿瘤肾脏病学专科,专门管理免疫效应疗法相关肾脏并发症。
Cell therapy, specifically the revolutionary chimeric antigen receptor (CAR) T-cell therapy, has transformed the landscape of oncology, making substantial strides in practical treatment approaches. Today, established guidelines for diseases such as lymphomas, myelomas, and leukemias actively advocate the utilization of these once-unconventional therapies. The practical impact of these therapies is underscored by their unparalleled efficacy, reshaping the way we approach and implement treatments in the realm of oncology.
However, CAR T-cell therapy, with its performance in anti-tumor aggression through cellular action and inflammatory response, also comes with various adverse events, one of which is kidney injury.
Therefore, the management of these side effects is extremely important. The integration of knowledge between oncologists and specialized nephrologists has led to the emergence of a new sub-area of expertise for onco-nephrologists specializing in managing kidney complications from immune effector therapies.
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