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背景至关重要:肿瘤微环境影响细胞疗法的成功

英文原题:Context matters: Tumor microenvironments impact cellular therapy success.

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Context matters: Tumor microenvironments impact cellular therapy success.

PubMed 2024/04/16(内容时间) Cell Rep Med Q1 · IF 14(JCR 2025)

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中文摘要

在最近的一篇出版物中,Locke等人展示了ZUMA-7试验中治疗前肿瘤活检的数据。他们的结果确定了肿瘤微环境(TME)背景和CD19表达水平是axicabtagene ciloleucel(axi-cel)反应的预后指标。

展开英文摘要原文

In a recent publication, Locke et al. present data from pretreatment tumor biopsies taken on the ZUMA-7 trial. Their results identify tumor microenvironment (TME) contexts and level of CD19 expression as prognostic indicators for responses to axicabtagene ciloleucel (axi-cel).

论文信息

作者
Darnell EP、Maus MV
单位
Cellular Immunotherapy Program, Mass General Cancer Center, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address: elijah_darnell@dfci.harvard.edu.United States
期刊
Cell reports. Medicine2024 Apr 16
原文标识
PubMed 38631291 · DOI 10.1016/j.xcrm.2024.101491