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基因组工程作为肿瘤治疗中的一种治疗策略:综合综述

英文原题:Genome Engineering as a Therapeutic Approach in Cancer Therapy: A Comprehensive Review.

查看英文原题

Genome Engineering as a Therapeutic Approach in Cancer Therapy: A Comprehensive Review.

PubMed 2024/02/05(内容时间) Adv Genet (Hoboken)

分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。

中文摘要

癌症是导致死亡的最主要原因之一。人类基因组随时间保持稳定。然而,人类活动和环境因素能够影响某些类型突变的流行率。这与外源物质的过度发展和工业扩张有关,后者正在扩大癌症发生的领域。针对癌症的免疫反应机制已被广泛研究。基因组编辑改变了人体内基于基因组的免疫治疗过程,并开启了癌症治疗的新时代。在本综述中,主要聚焦于近期的癌症免疫治疗和基因组工程技术的应用。

展开英文摘要原文

Cancer is one of the foremost causes of mortality. The human genome remains stable over time.

However, human activities and environmental factors have the power to influence the prevalence of certain types of mutations. This goes to the excessive progress of xenobiotics and industrial development that is expanding the territory for cancers to develop.

The mechanisms involved in immune responses against cancer are widely studied. Genome editing has changed the genome-based immunotherapy process in the human body and has opened a new era for cancer treatment. In this review, recent cancer immunotherapies and the use of genome engineering technology are largely focused on.

论文信息

作者
Gemayel J、Chebly A、Kourie H、Hanna C、Mheidly K、Mhanna M、Karam F、Ghoussaini D
第一作者单位
Faculty of Sciences Balamand University Beirut Lebanon.
通讯作者单位
Reviva Regenerative Medicine Center Bsalim Lebanon.
文献类型
综述
期刊
Advanced genetics (Hoboken, N.J.)2024 Mar
原文标识
PubMed 38465225 · DOI 10.1002/ggn2.202300201