CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
早幼粒细胞白血病锌指通过调节先天性和适应性免疫细胞谱系定向及功能，控制肺部 2 型免疫应答
英文原题：Promyelocytic leukemia zinc finger controls type 2 immune responses in the lungs by regulating lineage commitment and the function of innate and adaptive immune cells.
查看英文原题
Promyelocytic leukemia zinc finger controls type 2 immune responses in the lungs by regulating lineage commitment and the function of innate and adaptive immune cells.
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中文摘要
2型免疫反应对宿主防御至关重要，介导过敏和Th2高型哮喘。转录因子早幼粒细胞白血病锌指蛋白（PLZF）已成为肺部2型炎症的重要调节因子；然而，其确切机制仍不清楚。在这篇综述中，我们总结了关于PLZF控制固有淋巴样细胞（ILCs）、iNKT细胞、记忆T细胞、嗜碱性粒细胞和其他驱动2型反应的免疫细胞的发育和功能的最新发现。我们讨论了PLZF在Th2高型哮喘发病机制中的重要作用。总体而言，先前的研究揭示了PLZF在调节参与肺部2型炎症的固有免疫细胞和适应性免疫细胞中的关键作用。因此，靶向PLZF信号通路是抑制Th2高型哮喘的一种有前景的治疗方法。
展开英文摘要原文
Type 2 immune responses are critical for host defense, mediate allergy and Th2-high asthma. The transcription factor, promyelocytic leukemia zinc finger (PLZF), has emerged as a significant regulator of type 2 inflammation in the lung; however, its exact mechanism remains unclear. In this review, we summarized recent findings regarding the ability of PLZF to control the development and function of innate lymphoid cells (ILCs), iNKT cells, memory T cells, basophils, and other immune cells that drive type 2 responses.
We discussed the important role of PLZF in the pathogenesis of Th2-high asthma. Collectively, prior studies have revealed the critical role of PLZF in the regulation of innate and adaptive immune cells involved in type 2 inflammation in the lung.
Therefore, targeting PLZF signaling represents a promising therapeutic approach to suppress Th2-high asthma.
论文信息
- 作者
- Sha J、Zhang M、Feng J、Shi T、Li N、Jie Z
- 第一作者单位
- Department of Pulmonary and Critical Care Medicine, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.Germany
- 通讯作者单位
- Department of Pulmonary and Critical Care Medicine, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China; Center of Community-Based Health Research, Fudan University, Shanghai, China. Electronic address: jiezjlxh@163.com.Germany
- 文献类型
- 综述
- 期刊
- International immunopharmacology2024 Mar 30
- 原文标识
- PubMed 38373386 · DOI 10.1016/j.intimp.2024.111670