γδ T 细胞调节小细胞肺癌中的抗肿瘤免疫
γδ T cells modulate anti-tumor immunity in small cell lung cancer.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
非常规γδ T 细胞亚群在癌症中的全景
英文原题：Landscape of unconventional γδ T cell subsets in cancer.
查看英文原题
Landscape of unconventional γδ T cell subsets in cancer.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
T细胞大致分为两类，即常规T细胞和非常规T细胞。常规T细胞是最常见且研究最深入的T细胞亚群。另一方面，非常规T细胞表现出固有免疫细胞和适应性免疫细胞之间共享的多种功能。近几十年来，γδ T细胞因其在癌症免疫中的作用而受到关注。这些细胞能够识别多种分子，如脂质和代谢物。此外，它们以在肿瘤微环境（TME）中识别和靶向癌细胞的独特能力而闻名。γδ T细胞的这一特征可能为抗击癌症提供一种独特的治疗工具。了解γδ T细胞在TME中的作用对于为将γδ T细胞用于临床目的奠定基础至关重要。在此，我们提供关于γδ T细胞亚群在不同癌症类型中作用的最新知识。
展开英文摘要原文
T cells are broadly categorized into two groups, namely conventional and unconventional T cells. Conventional T cells are the most prevalent and well-studied subset of T cells. On the other hand, unconventional T cells exhibit diverse functions shared between innate and adaptive immune cells. During recent decades, γδ T cells have received attention for their roles in cancer immunity.
These cells can detect various molecules, such as lipids and metabolites. Also, they are known for their distinctive ability to recognize and target cancer cells in the tumor microenvironment (TME). This feature of γδ T cells could provide a unique therapeutic tool to fight against cancer. Understanding the role of γδ T cells in TME is essential to prepare the groundwork to use γδ T cells for clinical purposes.
Here, we provide recent knowledge regarding the role γδ T cell subsets in different cancer types.
论文信息
- 作者
- Azimnasab-Sorkhabi P、Soltani-Asl M、Soleiman Ekhtiyari M、Kfoury Junior JR
- 单位
- Department of Surgery, School of Veterinary Medicine and Animal Sciences, University of Sao Paulo, Sao Paulo, Brazil. Sorkhabi.parviz@gmail.com.Brazil
- 文献类型
- 综述
- 期刊
- Molecular biology reports2024 Jan 30
- 原文标识
- PubMed 38289417 · DOI 10.1007/s11033-024-09267-1