上消化道免疫相关不良事件：两例难治/复发性弥漫大 B 细胞淋巴瘤患者在接受序贯 CAR-T 细胞治疗联合自体造血干细胞移植后的免疫巩固治疗中发生梗阻性并发症

KEY CLINICAL MESSAGE: Immune checkpoint inhibitors are a very popular method of treating malignant tumors.

But its side effects cannot be ignored. This study revealed obstructive complications during immune consolidation therapy following sequential chimeric antigen receptor T cell therapy with autologous hematopoietic stem cell transplantation in two patients with diffuse large b cell lymphoma (DLBCL).

Both our patients had the same symptoms of vomiting and inability to eat due to pyloric obstruction, it should be highlighted that this is a relatively rare and irreversible complication of upper gastrointestinal caused by immune consolidation therapy. ABSTRACT: Immune checkpoint inhibitors (ICIs) have become the standard therapy for many malignant tumors.

However, ICIs are associated with unique immune-related adverse events (irAEs) caused by dysregulated immune activation and associated complications have been observed in patients.

Here, we report two cases of patients with pyloric obstruction and duodenal ulcers induced by the use of sintilimab, which provides some guidance for the widely used anti-programmed death-1 therapy. During the entire treatment progression for such patients, the correct differential diagnosis of adverse effects and the use of immunosuppressive agents such as glucocorticoids are essential to facilitate early prevention and intervention of irAEs.