不可逆电穿孔增强 CAR-T 细胞对实体瘤的浸润与选择性癌细胞裂解
Irreversible Electroporation Enhances Solid Tumor Infiltration and Selective Cancer Cell Lysis by CAR T Cells.
通过利用一种双用途转化策略——直接的癌细胞靶向细胞毒性和增强的 CAR-T 细胞浸润——sIRE 能够减轻肿瘤负荷，同时保持并增强 CAR-T 细胞功能。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
恶性胸膜间皮瘤的当前治疗格局与未来方向
英文原题：The Current Treatment Landscape of Malignant Pleural Mesothelioma and Future Directions.
查看英文原题
The Current Treatment Landscape of Malignant Pleural Mesothelioma and Future Directions.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
恶性胸膜间皮瘤的发病率预计在全球范围内将上升。人们迫切期待针对这种恶性肿瘤的新治疗方案，以改善患者的生存率和生活质量。本文重点介绍了该领域近期进展的结果，分析了几项相关试验的数据。异质性肿瘤微环境和生物学特性，加上低突变负荷，给此类肿瘤的治疗带来了挑战。迄今为止，尚无单一生物标志物与靶向治疗开发可靠相关；因此，通常需要联合策略来改善结局。局部应用的疫苗、基因工程免疫细胞群（如 T 细胞）的扩增、阻断抑制抗肿瘤反应的免疫检查点以及化学免疫治疗，是最有希望改变间皮瘤治疗格局的选择之一。
展开英文摘要原文
The incidence of malignant pleural mesothelioma is expected to increase globally. New treatment options for this malignancy are eagerly awaited to improve the survival and quality of life of patients. The present article highlights the results of recent advances in this field, analyzing data from several relevant trials. The heterogeneous tumor microenvironment and biology, together with the low mutational burden, pose a challenge for treating such tumors.
So far, no single biomarker has been soundly correlated with targeted therapy development; thus, combination strategies are often required to improve outcomes. Locally applied vaccines, the expansion of genetically engineered immune cell populations such as T cells, the blockage of immune checkpoints that inhibit anti-tumorigenic responses and chemoimmunotherapy are among the most promising options expected to change the mesothelioma treatment landscape.
论文信息
- 作者
- Bertin B、Zugman M、Schvartsman G
- 第一作者单位
- Faculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo 05651-901, Brazil.Israel
- 通讯作者单位
- Department of Medical Oncology, Hospital Israelita Albert Einstein, São Paulo 05651-901, Brazil.Israel
- 文献类型
- 综述
- 期刊
- Cancers2023 Dec 12
- 原文标识
- PubMed 38136353 · DOI 10.3390/cancers15245808