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骨肉瘤和神经母细胞瘤患者中的 GD2-CAR CAR T 细胞——起关键作用的不只是 T 细胞

英文原题:GD2-CAR CAR T cells in patients with osteosarcoma and neuroblastoma-it's not only the T cells that matter.

PubMed 2023/12/21(内容时间) Cancer Cell Q1 · IF 56.1(JCR 2025)

研究概要

GD2-CAR T 细胞是安全的,但抗肿瘤反应有限。

中文摘要

GD2-CAR T细胞安全性良好,但抗肿瘤应答有限。本期《Cancer Cell》中,Kaczanowska等人发现,在CAR-T扩增良好者中,单采产品和基线外周血均含有显著更高比例的CXCR3+单核细胞。CXCR3+单核细胞可能影响CAR-T细胞功能。

展开英文摘要原文

GD2-CAR T cells were safe and anti-tumor responses were limited. In this issue of Cancer Cell, Kaczanowska et al. find that apheresis products and peripheral blood at baseline contained significantly higher proportions of CXCR3+ monocytes in good expanders. CXCR3+ monocytes may influence CAR T cell function.

论文信息

作者
Arnett AB、Heczey A
第一作者单位
Center for Advanced Innate Cell Therapy, Houston, TX, USA.United States
通讯作者单位
Center for Advanced Innate Cell Therapy, Houston, TX, USA; Division of Pediatric Hematology and Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA; Texas Children's Cancer Center, Texas Children's Hospital, Houston, TX, USA. Electronic address: heczey@bcm.edu.United States
文献类型
非美国政府资助研究 · 评论
期刊
Cancer cell2024 Jan 8
原文标识
PubMed 38134937 · DOI 10.1016/j.ccell.2023.11.012