不适合移植的大 B 细胞淋巴瘤二线使用 axicabtagene ciloleucel：ALYCANTE 最终分析
Second-line axicabtagene ciloleucel in large B-cell lymphoma ineligible for transplantation: ALYCANTE final analysis.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
结外成熟 T 细胞和 NK 细胞淋巴瘤及淋巴增殖性疾病的生物学和遗传学
英文原题：Biology and genetics of extranodal mature T-cell and NKcell lymphomas and lymphoproliferative disorders.
查看英文原题
Biology and genetics of extranodal mature T-cell and NKcell lymphomas and lymphoproliferative disorders.
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中文摘要
结外成熟T细胞和NK细胞淋巴瘤及淋巴增殖性疾病代表了一组独特的罕见肿瘤，具有部分重叠且各具特点的临床病理学、生物学和基因组学特征。它们好发于特定部位，如胃肠道、呼吸消化道、肝、脾和皮肤/软组织，这构成了其分类的基础。近年来的基因组学进展加深了我们对这些疾病生物学和发病机制的理解，这对于准确诊断、预后评估和治疗决策至关重要。本文综述了以下结外成熟T细胞和NK细胞淋巴瘤及淋巴增殖性疾病的临床、病理、基因组和生物学特征：原发性肠道T细胞和NK细胞肿瘤、肝脾T细胞淋巴瘤、结外NK/T细胞淋巴瘤，鼻型，以及皮下脂膜炎样T细胞淋巴瘤。
展开英文摘要原文
The extranodal mature T-cell and NK-cell lymphomas and lymphoproliferative disorders represent a unique group of rare neoplasms with both overlapping and distinct clinicopathological, biological, and genomic features.
Their predilection for specific sites, such as the gastrointestinal tract, aerodigestive tract, liver, spleen, and skin/soft tissues, underlies their classification. Recent genomic advances have furthered our understanding of the biology and pathogenesis of these diseases, which is critical for accurate diagnosis, prognostic assessment, and therapeutic decision-making.
Here we review clinical, pathological, genomic, and biological features of the following extranodal mature T-cell and NK-cell lymphomas and lymphoproliferative disorders: primary intestinal T-cell and NK-cell neoplasms, hepatosplenic T-cell lymphoma, extranodal NK/T-cell lymphoma, nasal type, and subcutaneous panniculitis-like T-cell lymphoma.
论文信息
- 作者
- Lewis NE、Zhou T、Dogan A
- 单位
- Hematopathology Service, Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center. natashaelewis@gmail.com.United States
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Haematologica2023 Dec 1
- 原文标识
- PubMed 38037802 · DOI 10.3324/haematol.2023.282718
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