CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
滤泡辅助性 T 细胞：在淋巴瘤发生中的新作用
英文原题：Follicular helper T cells: emerging roles in lymphomagenesis.
查看英文原题
Follicular helper T cells: emerging roles in lymphomagenesis.
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中文摘要
滤泡辅助性T细胞是CD4+ T细胞的一个亚群，是形成生发中心的基础，而生发中心是抗体亲和力成熟和活化B细胞增殖的主要部位。过去10年来，人们对滤泡辅助性T细胞进行了广泛研究，尤其是其在癌症发生中的作用。本综述描述了正常滤泡辅助性T细胞的特征，并重点阐述了滤泡辅助性T细胞与淋巴瘤发生之间新出现的联系。淋巴瘤遗传学的进展极大地拓展了我们对滤泡辅助性T细胞在淋巴瘤发生中作用的理解。此外，我们详细介绍了多种药物和新疗法，主要聚焦于CAR-T 细胞疗法；这些新方法可能为淋巴瘤患者提供新的治疗机会。
展开英文摘要原文
Follicular helper T cells are a subset of CD4+ T cells that are fundamental to forming germinal centers, which are the primary sites of antibody affinity maturation and the proliferation of activated B cells. Follicular helper T cells have been extensively studied over the past 10 years, especially regarding their roles in cancer genesis.
This review describes the characteristics of normal follicular helper T cells and focuses on the emerging link between follicular helper T cells and lymphomagenesis. Advances in lymphoma genetics have substantially expanded our understanding of the role of follicular helper T cells in lymphomagenesis.
Moreover, we detail a range of agents and new therapies, with a major focus on chimeric antigen receptor T-cell therapy; these novel approaches may offer new treatment opportunities for patients with lymphomas.
论文信息
- 作者
- Wang JN、Zheng G、Wu W、Huang H
- 单位
- Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, No.79 Qingchun Road, Hangzhou, 311106, China.China
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Journal of leukocyte biology2024 Jun 28
- 原文标识
- PubMed 37939814 · DOI 10.1093/jleuko/qiad140