γδ T 细胞调节小细胞肺癌中的抗肿瘤免疫
γδ T cells modulate anti-tumor immunity in small cell lung cancer.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
卵巢癌中预后基因表达、肿瘤微环境与肿瘤浸润免疫细胞的相关性分析
英文原题：Correlation Analysis of Prognostic Gene Expression, Tumor Microenvironment, and Tumor-Infiltrating Immune Cells in Ovarian Cancer.
查看英文原题
Correlation Analysis of Prognostic Gene Expression, Tumor Microenvironment, and Tumor-Infiltrating Immune Cells in Ovarian Cancer.
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研究概要
因此，在 OC 微环境中，CD3E、CD3G、CD2、CD3D、CCL19 和 IL2RG 可作为潜在的免疫治疗靶点和预后标志物。
研究思路结论见上方概要
目的
肿瘤微环境（TME）研究可为癌症新型生物疗法的创新和持续改进提供关键方向。本研究探讨了卵巢癌（OC）中TME、肿瘤浸润免疫细胞表达谱与预后基因表达之间的关系。
方法
采用生物信息学方法对CD3E、CD3G、CD2、CD3D、CCL19和IL2RG进行了筛选。
结果
发现所有六个基因均参与免疫相关分子机制，并能调节肿瘤浸润细胞的表达。Kaplan-Meier生存分析结果表明，在OC患者中，总生存期与所有基因表达之间存在强烈关联。CIBERSORT分析结果显示，所有基因的表达水平与γδ T细胞比例呈正相关。
展开英文摘要原文
OBJECTIVE
Tumor microenvironment (TME) research can provide a crucial direction for the innovation and continuous improvement of novel biologic therapies for cancer. This study examined the relationship between the TME, expression profiles of the tumor-infiltrating immune cell, and prognostic gene expression in ovarian cancer (OC).
MATERIALS AND METHODS
Screening of CD3E, CD3G, CD2, CD3D, CCL19, and IL2RG was performed using the bioinformatics methods.
RESULTS
All six genes were found to participate in immune-related molecular mechanisms and could regulate the expression of tumor-infiltrating cells. A Kaplan-Meier survival analysis results demonstrated a strong association between overall survival and all gene expressions in patients with OC. CIBERSORT analysis results showed that the expression level of all genes was positively correlated with γδ T cell proportions.
CONCLUSION
Therefore, in the OC microenvironment, CD3E, CD3G, CD2, CD3D, CCL19, and IL2RG can be potential immunotherapy targets and prognostic markers.
论文信息
- 作者
- Li Q、Yang Z、Ling X、Ye J、Wu J、Wang Y、Yao C、Zheng J
- 第一作者单位
- Guangxi University of Chinese Medicine, Nanning 530000, Guangxi, China.China
- 通讯作者单位
- Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, Guangxi, China.China
- 期刊
- Disease markers2023
- 原文标识
- PubMed 37841886 · DOI 10.1155/2023/9672158
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