CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CD19CAR-T 细胞的单细胞图谱
英文原题：A single-cell atlas of CD19 chimeric antigen receptor T cells.
查看英文原题
A single-cell atlas of CD19 chimeric antigen receptor T cells.
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中文摘要
Li等展示了一项单细胞RNA测序（scRNA-seq）数据资源，这些数据来自接受标准治疗axicabtagene ciloleucel治疗的复发/难治性大B细胞淋巴瘤（rrLBCL）患者的输注产品，并通过PET/CT在3个月随访时识别出应答者和非应答者产品之间显著不同的特征，这是长期预后的重要标志。
展开英文摘要原文
Li et al. present a resource of single-cell RNA sequencing (scRNA-seq) data from the infusion products of relapsed or refractory large B cell lymphoma (rrLBCL) patients treated with standard-of-care axicabtagene ciloleucel and identify features that are significantly different between products from responders and non-responders at 3-month followup by PET/CT, an important landmark for long-term outcomes.
论文信息
- 作者
- Li X、Henderson J、Gordon MJ、Sheikh I、Nastoupil LJ、Westin J、Flowers C、Ahmed S
- 第一作者单位
- Department of Lymphoma & Myeloma, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.United States
- 通讯作者单位
- Department of Lymphoma & Myeloma, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: mgreen5@mdanderson.org.United States
- 文献类型
- 读者来信 · 美国 NIH 资助研究 · 美国政府（非公共卫生署）资助研究 · 非美国政府资助研究
- 期刊
- Cancer cell2023 Nov 13
- 原文标识
- PubMed 37738975 · DOI 10.1016/j.ccell.2023.08.015