CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
SOHO 最新进展与后续问题 | BTK 抑制剂治疗后进展的套细胞淋巴瘤患者的免疫治疗选择
英文原题：SOHO State of the Art Updates and Next Questions | Immunotherapeutic Options for Patients With Mantle Cell Lymphoma Who Progress on BTK Inhibitors.
查看英文原题
SOHO State of the Art Updates and Next Questions | Immunotherapeutic Options for Patients With Mantle Cell Lymphoma Who Progress on BTK Inhibitors.
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中文摘要
套细胞淋巴瘤是一种难治的 B 细胞非霍奇金淋巴瘤亚型，其侵袭性强，许多患者会复发或进入难治状态。Bruton 酪氨酸激酶抑制剂（BTKi）的引入显著改善了复发/难治性（R/R）套细胞淋巴瘤患者的治疗结局，但相当一部分患者最终仍会出现疾病进展或产生耐药。近年来，免疫治疗策略已成为有前景的治疗选择。随着 FDA 批准 CAR-T 细胞疗法，以及多种有前景的双特异性抗体和抗体药物偶联物进入临床开发，治疗格局正在快速演进。本文综述 R/R 套细胞淋巴瘤患者当前可用的免疫治疗选择。
展开英文摘要原文
Mantle cell lymphoma is a challenging subtype of B-cell non-Hodgkin lymphoma treat characterized by its aggressive nature and propensity for relapse or refractory (R/R) disease for many patients. The introduction of Bruton's tyrosine kinase inhibitors has significantly improved the outcomes for patients with R/R MCL, but a considerable proportion of patients eventually experience disease progression or develop resistance to these agents.
In recent years, immunotherapeutic approaches have emerged as promising treatment options. The treatment landscape is quickly progressing with the FDA approval of CAR-T cell therapy as well as several promising bispecific antibody therapies and antibody-drug conjugates in clinical development. This review article aims to provide a comprehensive overview of the current state of immunotherapeutic options available for patients with R/R MCL.
论文信息
- 作者
- Nayak RK、Gerber D、Zhang C、Cohen JB
- 第一作者单位
- Department of Hematology and Medical Oncology, Winship Cancer Institute at Emory University, Atlanta, GA.United States
- 通讯作者单位
- Department of Hematology and Medical Oncology, Winship Cancer Institute at Emory University, Atlanta, GA. Electronic address: jonathon.cohen@emory.edu.United States
- 文献类型
- 综述
- 期刊
- Clinical lymphoma, myeloma & leukemia2023 Dec
- 原文标识
- PubMed 37661513 · DOI 10.1016/j.clml.2023.08.011