不适合移植的大 B 细胞淋巴瘤二线使用 axicabtagene ciloleucel：ALYCANTE 最终分析
Second-line axicabtagene ciloleucel in large B-cell lymphoma ineligible for transplantation: ALYCANTE final analysis.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
分子技术推动皮肤 T 细胞淋巴瘤治疗的前沿进展
英文原题：Molecular techniques drive cutting edge advancements in management of cutaneous T cell lymphoma.
查看英文原题
Molecular techniques drive cutting edge advancements in management of cutaneous T cell lymphoma.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
皮肤 T 细胞淋巴瘤（CTCL）的特征是恶性 T 细胞浸润皮肤，并可能发生播散。由于疾病异质性、治疗耐药，以及缺少有效且标准化的诊断和预后临床工具，CTCL 的诊断和治疗仍具有挑战性。目前 CTCL 诊断实际上依赖临床表现、组织病理学和免疫组化，这些方法各自都存在敏感性和特异性方面的局限。令人鼓舞的是，流式细胞术、聚合酶链式反应、高通量测序和其他分子技术的近期进展，在改善 CTCL 诊断和治疗方面显示出前景。例如，通过测序进行 T 细胞受体克隆分型，有望在疾病早期检测 CTCL；单细胞 RNA 测序则可识别常见驱动 CTCL 发病机制的基因表达模式。上述技术的应用经验带来了新见解，可能转化为更优的 CTCL 诊断和治疗方法。
展开英文摘要原文
Cutaneous 5T cell lymphoma (CTCL), characterized by malignant T cells infiltrating the skin with potential for dissemination, remains a challenging disease to diagnose and treat due to disease heterogeneity, treatment resistance, and lack of effective and standardized diagnostic and prognostic clinical tools. Currently, diagnosis of CTCL practically relies on clinical presentation, histopathology, and immunohistochemistry. These methods are collectively fraught with limitations in sensitivity and specificity.
Fortunately, recent advances in flow cytometry, polymerase chain reaction, high throughput sequencing, and other molecular techniques have shown promise in improving diagnosis and treatment of CTCL.
Examples of these advances include T cell receptor clonotyping via sequencing to detect CTCL earlier in the disease course and single-cell RNA sequencing to identify gene expression patterns that commonly drive CTCL pathogenesis. Experience with these techniques has afforded novel insights which may translate into enhanced diagnostic and therapeutic approaches for CTCL.
论文信息
- 作者
- Lefebvre MN、Borcherding N、Reis RJ、Mou E、Liu V、Jabbari A
- 单位
- University of Iowa Carver College of Medicine, Iowa City, IA, United States.United States
- 文献类型
- 综述 · 美国 NIH 资助研究 · 美国政府（非公共卫生署）资助研究
- 期刊
- Frontiers in immunology2023
- 原文标识
- PubMed 37654486 · DOI 10.3389/fimmu.2023.1228563
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →