CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Tumor Immune Microenvironment in Gynecologic Cancers.
Tumor Immune Microenvironment in Gynecologic Cancers.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
妇科癌症对免疫治疗的缓解率各异，这是由不同癌症的分子生物学特征和肿瘤免疫微环境（TIME）异质性所致。本文综述TIME的关键特征及其在卵巢癌、子宫内膜癌、宫颈癌、外阴癌和阴道癌病理生理及治疗中的作用。随着大量临床前研究开展，人们对妇科癌症TIME作用的认识迅速发展；研究显示免疫系统作用复杂且具有两面性，既可支持癌症生长，也可抑制癌症并促进有效治疗。研究者已发现多种靶点和治疗手段，包括细胞因子、抗体、小分子、疫苗、过继性细胞疗法和细菌疗法，但多数在妇科癌症中的尝试尚未奏效。然而，随着免疫检查点抑制剂的发展，宫颈癌和子宫内膜癌治疗中已开始迅速、成功地应用免疫疗法。利用TIME开展治疗仍面临许多挑战，尤其在卵巢癌中；仍需进一步研究以鉴定并验证有效疗法。
Gynecologic cancers have varying response rates to immunotherapy due to the heterogeneity of each cancer's molecular biology and features of the tumor immune microenvironment (TIME). This article reviews key features of the TIME and its role in the pathophysiology and treatment of ovarian, endometrial, cervical, vulvar, and vaginal cancer.
Knowledge of the role of the TIME in gynecologic cancers has been rapidly developing with a large body of preclinical studies demonstrating an intricate yet dichotomous role that the immune system plays in either supporting the growth of cancer or opposing it and facilitating effective treatment. Many targets and therapeutics have been identified including cytokines, antibodies, small molecules, vaccines, adoptive cell therapy, and bacterial-based therapies but most efforts in gynecologic cancers to utilize them have not been effective.
However, with the development of immune checkpoint inhibitors, we have started to see the rapid and successful employment of therapeutics in cervical and endometrial cancer. There remain many challenges in utilizing the TIME, particularly in ovarian cancer, and further studies are needed to identify and validate efficacious therapeutics.
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →
MEMBER ACCOUNT
登录成功会直接打开下一页。
