CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CD4(+) T 细胞帮助髓系介导的免疫逃逸肿瘤杀伤
英文原题：CD4(+) T cells help myeloid-mediated killing of immune-evasive tumors.
查看英文原题
CD4(+) T cells help myeloid-mediated killing of immune-evasive tumors.
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中文摘要
在最近发表于Nature的一项研究中，Kruse等人展示了一种由少量CD4+效应T细胞协调的间接杀瘤机制。这些CD4+T细胞不仅能将髓系细胞重编程为IFNγ诱导的抗原提呈细胞，还能将其重编程为表达iNOS的杀瘤效应细胞，从而能够清除免疫逃逸性肿瘤。
展开英文摘要原文
In a recent study published in Nature, Kruse et al. demonstrated an indirect tumor-killing mechanism orchestrated by a small number of CD4 + effector T cells. These CD4 + T cells can reprogram myeloid cells not just into IFNγ-induced antigen-presenting cells but also into iNOS-expressing tumoricidal effectors that can eradicate immune-evasive tumors.
论文信息
- 作者
- Wu K、Fong L
- 第一作者单位
- Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.United States
- 通讯作者单位
- Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. Electronic address: lawrence.fong@ucsf.edu.United States
- 文献类型
- 美国 NIH 资助研究 · 非美国政府资助研究
- 期刊
- Trends in cancer2023 Oct
- 原文标识
- PubMed 37544796 · DOI 10.1016/j.trecan.2023.07.013