CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
弥漫性中线胶质瘤的 CAR-T 细胞治疗
英文原题：CAR T cell therapies for diffuse midline glioma.
查看英文原题
CAR T cell therapies for diffuse midline glioma.
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中文摘要
弥漫性中线胶质瘤（DMG）是一种致命的中枢神经系统（CNS）儿童肿瘤。DMG的发病位置和浸润性使其无法手术切除，姑息性放疗的获益也是暂时的；中位总生存期（OS）为9-11个月。肿瘤免疫微环境（TIME）呈“冷”状态，以免疫抑制性髓系细胞群为主导，浸润淋巴细胞和促炎分子水平较低。由于生存统计数据数十年来一直停滞不前，且迫切需要针对DMG独特生物学的疗法，这促使了嵌合抗原受体（CAR）T细胞疗法在该领域的临床评估。我们重点介绍CAR-T 细胞疗法治疗DMG的当前格局、TIME在治疗反应中可能发挥的作用，以及克服治疗障碍的策略。
展开英文摘要原文
Diffuse midline glioma (DMG) is a fatal pediatric cancer of the central nervous system (CNS). The location and infiltrative nature of DMG prevents surgical resection and the benefits of palliative radiotherapy are temporary; median overall survival (OS) is 9-11 months.
The tumor immune microenvironment (TIME) is 'cold', and has a dominant immunosuppressive myeloid compartment with low levels of infiltrating lymphocytes and proinflammatory molecules. Because survival statistics have been stagnant for many decades, and therapies targeting the unique biology of DMG are urgently needed, this has prompted the clinical assessment of chimeric antigen receptor (CAR) T cell therapies in this setting.
We highlight the current landscape of CAR T cell therapy for DMG, the role the TIME may play in the response, and strategies to overcome treatment obstacles.
论文信息
- 作者
- Thomas BC、Staudt DE、Douglas AM、Monje M、Vitanza NA、Dun MD
- 第一作者单位
- Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine, and Wellbeing, University of Newcastle, Callaghan, NSW, Australia; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.Australia
- 通讯作者单位
- Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine, and Wellbeing, University of Newcastle, Callaghan, NSW, Australia; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia; Paediatric Theme, Mark Hughes Foundation Centre for Brain Cancer Research, College of Health, Medicine, and Wellbeing, Callaghan, NSW, Australia. Electronic address: matt.dun@newcastle.edu.au.Australia
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Trends in cancer2023 Oct
- 原文标识
- PubMed 37541803 · DOI 10.1016/j.trecan.2023.07.007