CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Prognostic significance of ımmunhistochemical axl expression in pancreas ductal adenocarcinomas.
Prognostic significance of ımmunhistochemical axl expression in pancreas ductal adenocarcinomas.
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研究发现，Axl 表达增加已知会在癌变过程中促进 EMT 介导的转移，可能是 PDAC 患者局部扩散和不良预后的指标。在这方面，它有望作为 PDAC 患者个体化治疗中的靶向分子。
对2006-2017年间因PDAC接受手术的53例患者进行了回顾性评估。记录肿瘤特征：大小、淋巴血管侵犯（LVI）、神经周围侵犯（PNI）、切缘（RM）、淋巴结转移（LNM）、分化程度、TIL（肿瘤浸润淋巴细胞）、分期和总生存期。免疫组化方面，膜染色和/或细胞质染色被认为是Axl阳性。统计学上，在SPSS 21.0程序中使用Pearson卡方检验、Cox回归和Kaplan Mayer检验。
Axl在28例患者中呈阳性（52.8%）。Axl阳性与LVI的存在（P = 0.009）和LNM（P = 0.002）相关，并且是短生存期的独立预后因素（P = 0.006）。
Fifty-three patients who were operated on for PDAC between 2006-2017 were evaluated retrospectively. Features of tumors; size, lymphovascular invasion (LVI), perineural invasion (PNI), resection margin (RM), lymph node metastasis (LNM), differentiation, tumor-infiltrating lymphocyte, stage and overall survival were recorded. Immunohistochemically, membranous and or cytoplasmic staining was considered positive for Axl. Statistically, Pearson Chi-Square, Cox regression and Kaplan Mayer tests were used in the SPSS 21.0 program.
Axl was positive in 28 patients (52.8%). Axl positivity was found to be associated with the presence of LVI (P = 0.009) and LNM (P = 0.002) and was an independent prognostic factor in short survival (P = 0.006).
It was found that increased expression of Axl, which is known to increase EMT-mediated metastasis in carcinogenesis, may be an indicator of local spread and poor prognosis in PDAC patients. In this respect, it can be promising as a targeted molecule in PDAC patient's individualized treatments.
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