CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
儿童 CAR-T 治疗相关的严重持续性神经毒性
英文原题：Severe persistent neurotoxicity associated with CAR T therapy in children.
查看英文原题
Severe persistent neurotoxicity associated with CAR T therapy in children.
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中文摘要
CD19靶向嵌合抗原受体（CAR）T细胞疗法是复发/难治性急性淋巴细胞白血病的重要治疗手段，但其使用存在免疫效应细胞相关神经毒性综合征（ICANS）的风险。在儿童中，严重ICANS几乎普遍被报道与细胞因子释放综合征相关，且为可逆性。我们描述了两例在接受CAR-T 细胞治疗后出现严重、难治性神经毒性的儿童病例，这两例患儿均存在既往中枢神经系统（CNS）易感性。这些病例为非典型表现，起病延迟且独立于细胞因子释放综合征，并且对标准治疗无反应。
展开英文摘要原文
CD19-directed chimeric antigen receptor (CAR) T-cell therapy is an important therapy for relapsed or refractory acute lymphoblastic leukaemia, but its use carries the risk of immune effector cell-associated neurotoxicity syndrome (ICANS). In children, severe ICANS is almost universally reported in association with cytokine release syndrome and is reversible.
We describe two cases of severe, intractable neurotoxicity following CAR T-cell therapy in children with pre-existing central nervous system (CNS) vulnerabilities. The cases were atypical in their delayed onset and independence from cytokine release syndrome and did not respond to standard therapies.
论文信息
- 作者
- Andrew EC、Hughes D、Gilsenan M、Mignone C、Khaw SL、Wang SS
- 单位
- Children's Cancer Centre, Royal Children's Hospital, Parkville, Victoria, Australia.Australia
- 期刊
- British journal of haematology2023 Nov
- 原文标识
- PubMed 37528536 · DOI 10.1111/bjh.19015