CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Myeloid-Derived Suppressor Cells (MDSCs) in Ovarian Cancer-Looking Back and Forward.
Myeloid-Derived Suppressor Cells (MDSCs) in Ovarian Cancer-Looking Back and Forward.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
髓源性抑制细胞（MDSCs）在免疫系统中发挥重要作用，并已在癌症中得到广泛研究。MDSCs是一群异质性髓系细胞，在肿瘤微环境中积聚。因此，这些细胞的高丰度常导致免疫抑制、肿瘤生长、治疗失败和不良预后。卵巢癌在女性癌症死亡中排名第五，其死亡人数超过任何其他女性生殖道癌症。目前，缺乏有效的临床策略来治疗卵巢癌。尽管多项研究强调了人MDSCs在卵巢癌中的负面作用，但这一主题仍未得到充分研究。本文总结了关于MDSCs的研究，并解释了为何聚焦这些细胞将是治疗卵巢癌患者的一种有前景的方法。
Myeloid-derived suppressor cells (MDSCs) play a significant role in the immune system and have been extensively studied in cancer. MDSCs are a heterogeneous population of myeloid cells that accumulate in the tumor microenvironment. Consequently, the high abundance of these cells often leads to immunosuppression, tumor growth, treatment failure, and poor prognosis. Ovarian cancer ranks fifth in cancer deaths among women, accounting for more deaths than any other cancer of the female genital tract.
Currently, there is a lack of effective clinical strategies for the treatment of ovarian cancer. Although several studies underline the negative role of human MDSCs in ovarian cancer, this topic is still understudied. The works on MDSCs are summarized here, along with an explanation of why focusing on these cells would be a promising approach for treating ovarian cancer patients.
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →
MEMBER ACCOUNT
登录成功会直接打开下一页。
