CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Genome editing and cancer therapy: handling the hypoxia-responsive pathway as a promising strategy.
Genome editing and cancer therapy: handling the hypoxia-responsive pathway as a promising strategy.
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氧感知通路的精确表征以及pO2调控基因表达的鉴定都是至关重要的问题。O2感知系统在几乎所有关键的人类过程中都发挥着重要作用，包括干细胞特化、组织的生长发育（如胚胎发生）、中间代谢的调节（包括葡萄糖代谢从氧化性ATP产生向无氧ATP产生的转变及反向转变），以及血压的控制。实体癌微环境的特征在于低氧水平以及由此引发的缺氧反应激活，而后者又使得以新生血管生成和代谢重编程为主要特征的复杂适应性反应得以实现。近年来，分子遗传学方法学的惊人进展使得高效基因组编辑成为可能，更重要的是，能够精确鉴定靶细胞/组织。这些新的可能性以及对缺氧适应机制的了解，提示了基于对氧传感器系统分子机制的操控、靶向和利用来有效开发新治疗方法的可能。
The precise characterization of oxygen-sensing pathways and the identification of pO 2 -regulated gene expression are both issues of critical importance. The O 2 -sensing system plays crucial roles in almost all the pivotal human processes, including the stem cell specification, the growth and development of tissues (such as embryogenesis), the modulation of intermediate metabolism (including the shift of the glucose metabolism from oxidative to anaerobic ATP production and vice versa), and the control of blood pressure.
The solid cancer microenvironment is characterized by low oxygen levels and by the consequent activation of the hypoxia response that, in turn, allows a complex adaptive response characterized mainly by neoangiogenesis and metabolic reprogramming. Recently, incredible advances in molecular genetic methodologies allowed the genome editing with high efficiency and, above all, the precise identification of target cells/tissues.
These new possibilities and the knowledge of the mechanisms of adaptation to hypoxia suggest the effective development of new therapeutic approaches based on the manipulation, targeting, and exploitation of the oxygen-sensor system molecular mechanisms.
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →
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